plathlab

Using molecular dynamics simulations to prioritize and understand AI-generated

Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.

Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides

Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
plathlab
plathlab
Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10
APR10588G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E
Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10
AMM04145G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E
Flotillin-1 Mouse Monoclonal Antibody(6C10)
38095-100ul 100ul
EUR 252
Flotillin-1 Mouse Monoclonal Antibody(6C10)
38095-50ul 50ul
EUR 187
TNF-α Rabbit pAb
A11534-100ul 100 ul
EUR 308
TNF-α Rabbit pAb
A11534-200ul 200 ul
EUR 459
TNF-α Rabbit pAb
A11534-20ul 20 ul
EUR 183
TNF-α Rabbit pAb
A11534-50ul 50 ul
EUR 223
TNF-α Rabbit pAb
A0277-100ul 100 ul
EUR 308
TNF-α Rabbit pAb
A0277-200ul 200 ul
EUR 459
TNF-α Rabbit pAb
A0277-20ul 20 ul
EUR 183
TNF-α Rabbit pAb
A0277-50ul 50 ul
EUR 223
TNF-α, His, Human
HY-P7416 50ug
EUR 302
TNF-α, His, Mouse
HY-P7417 50ug
EUR 486
Monkey TNF-α ELISPOT antibody pair
CT617-10 10-plate
EUR 528
Monkey TNF-α ELISPOT antibody pair
CT617-20 20-plate
EUR 923
Human TNF-α ELISPOT antibody pair
CT647-10 10-plate
EUR 528
Human TNF-α ELISPOT antibody pair
CT647-20 20-plate
EUR 923
Mouse TNF-α ELISPOT antibody pair
CT661-10 10-plate
EUR 528
Mouse TNF-α ELISPOT antibody pair
CT661-20 20-plate
EUR 923
Rat TNF-α ELISA antibody pair
CT704-10 10-plate
EUR 547
Rat TNF-α ELISA antibody pair
CT704-20 20-plate
EUR 932
Monkey TNF-α ELISA antibody pair
CT717-10 10-plate
EUR 547
Monkey TNF-α ELISA antibody pair
CT717-20 20-plate
EUR 932
Human TNF-α ELISA antibody pair
CT747-10 10-plate
EUR 547
Human TNF-α ELISA antibody pair
CT747-20 20-plate
EUR 932
Mouse TNF-α ELISA antibody pair
CT761-10 10-plate
EUR 547
Mouse TNF-α ELISA antibody pair
CT761-20 20-plate
EUR 932
Marmoset TNF-α ELISA antibody pair
CT772-10 10-plate
EUR 547
Marmoset TNF-α ELISA antibody pair
CT772-20 20-plate
EUR 932
Marmoset TNF-α ELISPOT antibody pair
CT962-10 10-plate
EUR 528
Marmoset TNF-α ELISPOT antibody pair
CT962-20 20-plate
EUR 923
Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative
100-210-TNF 1 kit
EUR 482
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)
44100-100ul 100ul
EUR 252
TNF ? Monoclonal Antibody
EM1197-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC
TNF ? Monoclonal Antibody
EM1197-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α
C082-10ug 10ug
EUR 168
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α
C082-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α
C082-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α
C082-50ug 50ug
EUR 405
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.
Swine TNF-α ELISA Kit
DEIA-T6108 96T
EUR 533
Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product.
Mouse TNF-α ELISA kit
DEIA7391 96T
EUR 741
Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support.
Rat TNF-α ELISA kit
CT075A 5-plate
EUR 462
Monkey TNF-α ELISPOT kit
CT133-PB2 2-plate
EUR 415
Monkey TNF-α ELISPOT kit
CT133-PB5 5-plate
EUR 568
Monkey TNF-α ELISPOT kit
CT133-PR2 2-plate
EUR 415
Monkey TNF-α ELISPOT kit
CT133-PR5 5-plate
EUR 556
Monkey TNF-α ELISPOT kit
CT133-T2 2-plate
EUR 360
Monkey TNF-α ELISPOT kit
CT133-T5 5-plate
EUR 579
Monkey TNF-α ELISA kit
CT148A 5-plate
EUR 462
Human TNF-α ELISA kit
CT209A 5-plate
EUR 462
Human TNF-α ELISPOT kit
CT237-PB2 2-plate
EUR 415
Human TNF-α ELISPOT kit
CT237-PB5 5-plate
EUR 568
Human TNF-α ELISPOT kit
CT237-PR2 2-plate
EUR 415
Human TNF-α ELISPOT kit
CT237-PR5 5-plate
EUR 556
Human TNF-α ELISPOT kit
CT237-T2 2-plate
EUR 360
Human TNF-α ELISPOT kit
CT237-T5 5-plate
EUR 579
Mouse TNF-α ELISA kit
CT303A 5-plate
EUR 462
Mouse TNF-α ELISPOT kit
CT322-PB2 2-plate
EUR 415
Mouse TNF-α ELISPOT kit
CT322-PB5 5-plate
EUR 568
Mouse TNF-α ELISPOT kit
CT322-PR2 2-plate
EUR 415
Mouse TNF-α ELISPOT kit
CT322-PR5 5-plate
EUR 556
Mouse TNF-α ELISPOT kit
CT322-T2 2-plate
EUR 360
Mouse TNF-α ELISPOT kit
CT322-T5 5-plate
EUR 579
Marmoset TNF-α ELISA kit
CT342A 5-plate
EUR 462
Marmoset TNF-α ELISPOT kit
CT938-PR2 2-plate
EUR 415
Marmoset TNF-α ELISPOT kit
CT938-PR5 5-plate
EUR 556
human TNF-α,His tag
E410A13-10 100μg
EUR 694
TNF-α (31-45), human
HY-P1860 1mg
EUR 360
Recombinant Mouse TNF α Protein
RP00816 10 μg
EUR 183
α-SMA Monoclonal Antibody
40482-100ul 100ul
EUR 252
α-SMA Monoclonal Antibody
40482-50ul 50ul
EUR 187
α-SMA Monoclonal Antibody
40495-100ul 100ul
EUR 252
α-SMA Monoclonal Antibody
40495-50ul 50ul
EUR 187
anti-STAT6 (6C10)
LF-MA10315 50 ug
EUR 363
Description: Mouse monoclonal to STAT6
Anti-STAT6 (6C10)
YF-MA15643 200 ul
EUR 363
Description: Mouse monoclonal to STAT6
Anti-BRD3 (6C10)
YF-MA16265 50 ug
EUR 363
Description: Mouse monoclonal to BRD3
Anti-BRD3 (6C10)
YF-MA16266 200 ul
EUR 363
Description: Mouse monoclonal to BRD3
Anti-TNF-α (Golimumab), Human IgG1 Antibody
A2141-100 100 µg
EUR 510
Anti-TNF-α (Certolizumab Pegol), Humanized Antibody
A2142-100 100 µg
EUR 510
Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit
EHA0004 96T
EUR 567.6
  • Detection range: 3.12-200 pg/ml
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 1.875pg/ml
Goat Tumor necrosis factor α,TNF-α ELISA KIT
CN-00367S1 96T
EUR 457
Goat Tumor necrosis factor α,TNF-α ELISA KIT
CN-00367S2 48T
EUR 306
PoFAine tumor necrosis factor α,TNF-α ELISA Kit
CN-01217P1 96T
EUR 470
PoFAine tumor necrosis factor α,TNF-α ELISA Kit
CN-01217P2 48T
EUR 320
Rat Tumor necrosis factor α,TNF-α ELISA KIT
CN-01587R1 96T
EUR 442
Rat Tumor necrosis factor α,TNF-α ELISA KIT
CN-01587R2 48T
EUR 293
Monkey Tumor necrosis factor α,TNF-α ELISA KIT
CN-02231M1 96T
EUR 494
Monkey Tumor necrosis factor α,TNF-α ELISA KIT
CN-02231M2 48T
EUR 344
Mouse Tumor necrosis factor α,TNF-α ELISA KIT
CN-02415M1 96T
EUR 457
Mouse Tumor necrosis factor α,TNF-α ELISA KIT
CN-02415M2 48T
EUR 306
Human Tumor necrosis factor α,TNF-α ELISA KIT
CN-03277H1 96T
EUR 452
Human Tumor necrosis factor α,TNF-α ELISA KIT
CN-03277H2 48T
EUR 302
Bovine tumor necrosis factor α(TNF-α)ELISA KIT
GA-E0017BV-48T 48T
EUR 336
Bovine tumor necrosis factor α(TNF-α)ELISA KIT
GA-E0017BV-96T 96T
EUR 534
Rat Tumor necrosis factor α(TNF-α)ELISA Kit
GA-E0772RT-48T 48T
EUR 317
Rat Tumor necrosis factor α(TNF-α)ELISA Kit
GA-E0772RT-96T 96T
EUR 496
Human Tumor necrosis factor α(TNF-α)ELISA Kit
GA-E0122HM-48T 48T
EUR 289
Human Tumor necrosis factor α(TNF-α)ELISA Kit
GA-E0122HM-96T 96T
EUR 466
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT
GA-E0130MS-48T 48T
EUR 336
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT
GA-E0130MS-96T 96T
EUR 534
Human Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E00182 96T
EUR 361
Rat Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E10880 96T
EUR 361
Goat Tumor necrosis factor α,TNF-α ELISA KIT
QY-E140007 96T
EUR 413
Sheep Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E140060 96T
EUR 413
Mouse Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E21543 96T
EUR 361
Porcine tumor necrosis factor α,TNF-α ELISA Kit
QY-E40006 96T
EUR 394
Bovine Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E60007 96T
EUR 426
Canine Tumor necrosis factor α,TNF-α ELISA Kit
QY-E70025 96T
EUR 426
Chicken Tumor necrosis factor α,TNF-α ELISA KIT
QY-E80030 96T
EUR 426
TNF Alpha Monoclonal Antibody
ABM40205-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
TNF Alpha Monoclonal Antibody
ABM40205-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
TNF Alpha Monoclonal Antibody
ABM40205-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
TNF Alpha Monoclonal Antibody
ABM40206-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
TNF Alpha Monoclonal Antibody
ABM40206-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
TNF Alpha Monoclonal Antibody
ABM40206-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
pAb rabbit anti-rat TNF-α
CT062 0.5 mg
EUR 184
mAb mouse anti-human TNF-α
CT258 0.5 mg
EUR 260
mAb mouse anti-human TNF-α
CT260 0.5 mg
EUR 260
mAb mouse anti-human TNF-α
CT271 0.5 mg
EUR 260
Recombinant mouse TNF-α (E.coli-derived)
CT304 10 µg
EUR 243
Recombinant mouse TNF-α (E.coli-derived)
CT305 100 µg
EUR 598
pAb rabbit anti-mouse TNF-α
CT315 0.5 mg
EUR 184
TNF-α (31-45), human (TFA)
HY-P1860A 5mg
EUR 980
Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit
CN-00228G1 96T
EUR 470
Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit
CN-00228G2 48T
EUR 320
Guinea pig Tumor necrosis factor α(TNF-α)ELISA Kit
QY-E90069 96T
EUR 478
α-tubulin Mouse Monoclonal Antibody
37981-100ul 100ul
EUR 252
α-tubulin Mouse Monoclonal Antibody
37981-50ul 50ul
EUR 187
HSP90 α Monoclonal antibody(1F6)
44076-100ul 100ul
EUR 252
HSP90 α Monoclonal antibody(7D6)
44078-100ul 100ul
EUR 252
Anti-Thioredoxin / TRX (6C10)
YF-MA15994 100 ug
EUR 363
Description: Mouse monoclonal to Thioredoxin / TRX
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant
C036-10ug 10ug
EUR 151
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant
C036-1mg 1mg
EUR 1795
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant
C036-500ug 500ug
EUR 1273
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant
C036-50ug 50ug
EUR 344
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Human IFN-γ / TNF-α FluoroSpot kit
CT851-F2 2-plate
EUR 579
Monkey IFN-γ / TNF-α FluoroSpot kit
CT901-F2 2-plate
EUR 579
17-α-hydoxy progesterone monoclonal antibody
10R-11483 1 mg
EUR 743
Description: Mouse anti-17-α-hydoxy progesterone monoclonal antibody
pAb rabbit anti-rat TNF-α Biotin-labeled
CT064 0.5 mg
EUR 347
pAb rabbit anti-mouse TNF-α Biotin labeled
CT332 0.5 mg
EUR 347
Human TNF α converting enzyme,TACE ELISA Kit
CN-03416H1 96T
EUR 463
Human TNF α converting enzyme,TACE ELISA Kit
CN-03416H2 48T
EUR 312
Human TNF α converting enzyme(TACE)ELISA Kit
GA-E0865HM-48T 48T
EUR 289
Human TNF α converting enzyme(TACE)ELISA Kit
GA-E0865HM-96T 96T
EUR 466
Human TNF α converting enzyme(TACE)ELISA Kit
QY-E00180 96T
EUR 361
Monoclonal TNF alpha Antibody, Clone: EP1085Y
APR10496G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB
Mouse anti Canine TNF monoclonal antibody
CABT-L129 500ug
EUR 819
Mouse anti Rat TNF monoclonal antibody
CABT-L378 100ug
EUR 715
Mouse anti Porcine TNF monoclonal antibody
CABT-L382 500ug
EUR 840
Mouse anti Porcine TNF monoclonal antibody
CABT-L383 250 ug
EUR 892
Monoclonal TNF-alpha Antibody, Clone: 2A9B9
APR13767G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E
TNF Receptor II recombinant monoclonal antibody
A5046 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA
α tubulin Mouse Monoclonal Antibody(Zebrafish Specific)
38059-100ul 100ul
EUR 252
α tubulin Mouse Monoclonal Antibody(Zebrafish Specific)
38059-50ul 50ul
EUR 187
α-tubulin (Acetyl Lys40) Monoclonal Antibody(5H5)
HW204-100ul 100ul
EUR 252
Canine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
ECA0020 96T
EUR 567.6
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P51742
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 9.375pg/ml
Bovine TNF-α(Tumor necrosis factor alpha) ELISA Kit
EB0008 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: Q06599
  • Alias: TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 0.094 ng/ml
Rat TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
ER1393 96T
EUR 476.25
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P16599
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml
Rabbit TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
ERB0126 96T
EUR 567.6
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P04924
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml
Sheep TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
ESH0025 96T
EUR 567.6
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P23383
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml
Monkey TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
EMK0079 96T
EUR 567.6
  • Detection range: 31.25-2000 pg/ml
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 18.75pg/ml
Porcine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
EP0159 96T
EUR 567.6
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: P23563
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml
Camel Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit
QY-E120067 96T
EUR 478
Mouse anti Guinea Pig TNF monoclonal antibody
CABT-L155 500ug
EUR 819
Mouse anti Guinea Pig TNF monoclonal antibody
CABT-L156 250ug
EUR 881
Rat anti Rhesus Macaque TNF monoclonal antibody
CABT-L376 500ug
EUR 819
Anti-TNF Receptor II Rabbit Monoclonal Antibody
M01437 100ug/vial
EUR 397
Description: Rabbit Monoclonal TNF Receptor II Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.
α Skeletal Muslce Actin Mouse Monoclonal Antibody(4B11)
38090-100ul 100ul
EUR 252
α Skeletal Muslce Actin Mouse Monoclonal Antibody(4B11)
38090-50ul 50ul
EUR 187
α-tubulin (Acetyl Lys40) Monoclonal Antibody(4A8)(4A8)
HW203-100ul 100ul
EUR 252
Guinea pig TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
EGP0049 96T
EUR 567.6
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: P51435
  • Alias: TNFα(Tumor Necrosis Factor Alpha)/TNF-α/DIF/TNF-alpha/TNFA/TNFSF2
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 9.375pg/ml
TNF Antibody
35963-100ul 100ul
EUR 252
TNF antibody
38122-100ul 100ul
EUR 252
TNF ?? Antibody
39389-100ul 100ul
EUR 390
TNF Antibody
1-CSB-PA004310
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000
TNF Antibody
1-CSB-PA004963
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000
TNF Antibody
1-CSB-PA07427A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200
TNF Antibody
1-CSB-PA080266
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:500-1:2000
TNF Antibody
1-CSB-PA080267
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:500-1:2000.IHC:1:50-1:200
TNF Antibody
1-CSB-PA08474A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Bovine. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000
TNF Antibody
CSB-PA147864-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500
TNF Antibody
CSB-PA147864-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500
TNF Antibody
1-CSB-PA954619
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100
TNF Antibody
DF6080 200ul
EUR 304
Description: TNF Antibody detects endogenous levels of total TNF.
TNF Antibody
1-CSB-PA023955DA01SH
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Sheep. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000
TNF Antibody
CSB-PA023955KA01HU-
EUR 335
  • Form: liquid
  • Buffer: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100
TNF Antibody
CSB-PA023955KA01HU-100ul 100ul
EUR 389
  • Form: liquid
  • Buffer: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100
TNF Antibody
ABD6080 100 ug
EUR 438
Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8
APR10497G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P
α-Internexin Antibody
21638-100ul 100ul
EUR 252
α-Internexin Antibody
21638-50ul 50ul
EUR 187
PDGFR α Antibody
33470-100ul 100ul
EUR 252
PDGFR α Antibody
33470-50ul 50ul
EUR 187
Tubulin α Antibody
33531-100ul 100ul
EUR 252

Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion

Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.

Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness

A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
  • We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
  • Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
  • Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
  • Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
  • Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.

 

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