Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.
Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides
Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
 (M04), Clone: 6C10) Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10 |
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| APR10588G | Leading Biology | 0.1mg | EUR 484 |
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Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E |
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 (M01), Clone: 6C10) Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10 |
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| AMM04145G | Leading Biology | 0.05mg | EUR 484 |
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Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E |
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) Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-100ul | SAB | 100ul | EUR 252 |
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Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-50ul | SAB | 50ul | EUR 187 |
 TNF-α Rabbit pAb |
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| A11534-100ul | Abclonal | 100 ul | EUR 308 |
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TNF-α Rabbit pAb |
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| A11534-200ul | Abclonal | 200 ul | EUR 459 |
|
TNF-α Rabbit pAb |
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| A11534-20ul | Abclonal | 20 ul | EUR 183 |
|
TNF-α Rabbit pAb |
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| A11534-50ul | Abclonal | 50 ul | EUR 223 |
|
TNF-α Rabbit pAb |
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| A0277-100ul | Abclonal | 100 ul | EUR 308 |
|
TNF-α Rabbit pAb |
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| A0277-200ul | Abclonal | 200 ul | EUR 459 |
|
TNF-α Rabbit pAb |
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| A0277-20ul | Abclonal | 20 ul | EUR 183 |
|
TNF-α Rabbit pAb |
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| A0277-50ul | Abclonal | 50 ul | EUR 223 |
 TNF-α, His, Human |
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| HY-P7416 | MedChemExpress | 50ug | EUR 302 |
 TNF-α, His, Mouse |
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| HY-P7417 | MedChemExpress | 50ug | EUR 486 |
 Monkey TNF-α ELISPOT antibody pair |
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| CT617-10 | U-CyTech | 10-plate | EUR 528 |
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Monkey TNF-α ELISPOT antibody pair |
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| CT617-20 | U-CyTech | 20-plate | EUR 923 |
 Human TNF-α ELISPOT antibody pair |
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| CT647-10 | U-CyTech | 10-plate | EUR 528 |
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Human TNF-α ELISPOT antibody pair |
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| CT647-20 | U-CyTech | 20-plate | EUR 923 |
 Mouse TNF-α ELISPOT antibody pair |
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| CT661-10 | U-CyTech | 10-plate | EUR 528 |
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Mouse TNF-α ELISPOT antibody pair |
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| CT661-20 | U-CyTech | 20-plate | EUR 923 |
 Rat TNF-α ELISA antibody pair |
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| CT704-10 | U-CyTech | 10-plate | EUR 547 |
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Rat TNF-α ELISA antibody pair |
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| CT704-20 | U-CyTech | 20-plate | EUR 932 |
 Monkey TNF-α ELISA antibody pair |
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| CT717-10 | U-CyTech | 10-plate | EUR 547 |
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Monkey TNF-α ELISA antibody pair |
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| CT717-20 | U-CyTech | 20-plate | EUR 932 |
 Human TNF-α ELISA antibody pair |
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| CT747-10 | U-CyTech | 10-plate | EUR 547 |
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Human TNF-α ELISA antibody pair |
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| CT747-20 | U-CyTech | 20-plate | EUR 932 |
 Mouse TNF-α ELISA antibody pair |
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| CT761-10 | U-CyTech | 10-plate | EUR 547 |
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Mouse TNF-α ELISA antibody pair |
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| CT761-20 | U-CyTech | 20-plate | EUR 932 |
 Marmoset TNF-α ELISA antibody pair |
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| CT772-10 | U-CyTech | 10-plate | EUR 547 |
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Marmoset TNF-α ELISA antibody pair |
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| CT772-20 | U-CyTech | 20-plate | EUR 932 |
 Marmoset TNF-α ELISPOT antibody pair |
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| CT962-10 | U-CyTech | 10-plate | EUR 528 |
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Marmoset TNF-α ELISPOT antibody pair |
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| CT962-20 | U-CyTech | 20-plate | EUR 923 |
 Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative |
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| 100-210-TNF | Alpha Diagnostics | 1 kit | EUR 482 |
 Monoclonal Antibody(6C10)) P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| 44100-100ul | SAB | 100ul | EUR 252 |
 TNF ? Monoclonal Antibody |
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| EM1197-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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|
TNF ? Monoclonal Antibody |
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| EM1197-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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 Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-10ug | Novoprotein | 10ug | EUR 168 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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|
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-1mg | Novoprotein | 1mg | EUR 2283 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-500ug | Novoprotein | 500ug | EUR 1613 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-50ug | Novoprotein | 50ug | EUR 405 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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 Swine TNF-α ELISA Kit |
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| DEIA-T6108 | Creative Diagnostics | 96T | EUR 533 |
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Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product. |
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 Mouse TNF-α ELISA kit |
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| DEIA7391 | Creative Diagnostics | 96T | EUR 741 |
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Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support. |
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 Rat TNF-α ELISA kit |
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| CT075A | U-CyTech | 5-plate | EUR 462 |
 Monkey TNF-α ELISPOT kit |
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| CT133-PB2 | U-CyTech | 2-plate | EUR 415 |
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Monkey TNF-α ELISPOT kit |
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| CT133-PB5 | U-CyTech | 5-plate | EUR 568 |
|
Monkey TNF-α ELISPOT kit |
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| CT133-PR2 | U-CyTech | 2-plate | EUR 415 |
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Monkey TNF-α ELISPOT kit |
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| CT133-PR5 | U-CyTech | 5-plate | EUR 556 |
|
Monkey TNF-α ELISPOT kit |
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| CT133-T2 | U-CyTech | 2-plate | EUR 360 |
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Monkey TNF-α ELISPOT kit |
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| CT133-T5 | U-CyTech | 5-plate | EUR 579 |
 Monkey TNF-α ELISA kit |
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| CT148A | U-CyTech | 5-plate | EUR 462 |
 Human TNF-α ELISA kit |
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| CT209A | U-CyTech | 5-plate | EUR 462 |
 Human TNF-α ELISPOT kit |
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| CT237-PB2 | U-CyTech | 2-plate | EUR 415 |
|
Human TNF-α ELISPOT kit |
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| CT237-PB5 | U-CyTech | 5-plate | EUR 568 |
|
Human TNF-α ELISPOT kit |
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| CT237-PR2 | U-CyTech | 2-plate | EUR 415 |
|
Human TNF-α ELISPOT kit |
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| CT237-PR5 | U-CyTech | 5-plate | EUR 556 |
|
Human TNF-α ELISPOT kit |
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| CT237-T2 | U-CyTech | 2-plate | EUR 360 |
|
Human TNF-α ELISPOT kit |
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| CT237-T5 | U-CyTech | 5-plate | EUR 579 |
|
Mouse TNF-α ELISA kit |
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| CT303A | U-CyTech | 5-plate | EUR 462 |
 Mouse TNF-α ELISPOT kit |
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| CT322-PB2 | U-CyTech | 2-plate | EUR 415 |
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Mouse TNF-α ELISPOT kit |
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| CT322-PB5 | U-CyTech | 5-plate | EUR 568 |
|
Mouse TNF-α ELISPOT kit |
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| CT322-PR2 | U-CyTech | 2-plate | EUR 415 |
|
Mouse TNF-α ELISPOT kit |
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| CT322-PR5 | U-CyTech | 5-plate | EUR 556 |
|
Mouse TNF-α ELISPOT kit |
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| CT322-T2 | U-CyTech | 2-plate | EUR 360 |
|
Mouse TNF-α ELISPOT kit |
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| CT322-T5 | U-CyTech | 5-plate | EUR 579 |
 Marmoset TNF-α ELISA kit |
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| CT342A | U-CyTech | 5-plate | EUR 462 |
 Marmoset TNF-α ELISPOT kit |
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| CT938-PR2 | U-CyTech | 2-plate | EUR 415 |
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Marmoset TNF-α ELISPOT kit |
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| CT938-PR5 | U-CyTech | 5-plate | EUR 556 |
 human TNF-α，His tag |
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| E410A13-10 | EnoGene | 100μg | EUR 694 |
, human) TNF-α (31-45), human |
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| HY-P1860 | MedChemExpress | 1mg | EUR 360 |
 Recombinant Mouse TNF α Protein |
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| RP00816 | Abclonal | 10 μg | EUR 183 |
 α-SMA Monoclonal Antibody |
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| 40482-100ul | SAB | 100ul | EUR 252 |
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α-SMA Monoclonal Antibody |
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| 40482-50ul | SAB | 50ul | EUR 187 |
|
α-SMA Monoclonal Antibody |
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| 40495-100ul | SAB | 100ul | EUR 252 |
|
α-SMA Monoclonal Antibody |
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| 40495-50ul | SAB | 50ul | EUR 187 |
) anti-STAT6 (6C10) |
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| LF-MA10315 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse monoclonal to STAT6 |
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) Anti-STAT6 (6C10) |
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| YF-MA15643 | Abfrontier | 200 ul | EUR 363 |
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Description: Mouse monoclonal to STAT6 |
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) Anti-BRD3 (6C10) |
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| YF-MA16265 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse monoclonal to BRD3 |
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Anti-BRD3 (6C10) |
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| YF-MA16266 | Abfrontier | 200 ul | EUR 363 |
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Description: Mouse monoclonal to BRD3 |
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, Human IgG1 Antibody) Anti-TNF-α (Golimumab), Human IgG1 Antibody |
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| A2141-100 | Biovision | 100 µg | EUR 510 |
, Humanized Antibody) Anti-TNF-α (Certolizumab Pegol), Humanized Antibody |
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| A2142-100 | Biovision | 100 µg | EUR 510 |
 ELISA Kit) Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit |
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| EHA0004 | FN Test | 96T | EUR 567.6 |
|
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|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 1.875pg/ml |
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 Goat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-00367S1 | ChemNorm | 96T | EUR 457 |
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Goat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-00367S2 | ChemNorm | 48T | EUR 306 |
 PoFAine tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-01217P1 | ChemNorm | 96T | EUR 470 |
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PoFAine tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-01217P2 | ChemNorm | 48T | EUR 320 |
 Rat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-01587R1 | ChemNorm | 96T | EUR 442 |
|
Rat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-01587R2 | ChemNorm | 48T | EUR 293 |
 Monkey Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02231M1 | ChemNorm | 96T | EUR 494 |
|
Monkey Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02231M2 | ChemNorm | 48T | EUR 344 |
 Mouse Tumor necrosis factor α,TNF-α ELISA KIT |
|||
| CN-02415M1 | ChemNorm | 96T | EUR 457 |
|
Mouse Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02415M2 | ChemNorm | 48T | EUR 306 |
 Human Tumor necrosis factor α,TNF-α ELISA KIT |
|||
| CN-03277H1 | ChemNorm | 96T | EUR 452 |
|
Human Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-03277H2 | ChemNorm | 48T | EUR 302 |
ELISA KIT) Bovine tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0017BV-48T | GenAsia Biotech | 48T | EUR 336 |
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Bovine tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0017BV-96T | GenAsia Biotech | 96T | EUR 534 |
ELISA Kit) Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| GA-E0772RT-48T | GenAsia Biotech | 48T | EUR 317 |
|
Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| GA-E0772RT-96T | GenAsia Biotech | 96T | EUR 496 |
ELISA Kit) Human Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| GA-E0122HM-48T | GenAsia Biotech | 48T | EUR 289 |
|
Human Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| GA-E0122HM-96T | GenAsia Biotech | 96T | EUR 466 |
ELISA KIT) Mouse Tumor necrosis factor α(TNF-α)ELISA KIT |
|||
| GA-E0130MS-48T | GenAsia Biotech | 48T | EUR 336 |
|
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT |
|||
| GA-E0130MS-96T | GenAsia Biotech | 96T | EUR 534 |
|
Human Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| QY-E00182 | Qayee Biotechnology | 96T | EUR 361 |
|
Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| QY-E10880 | Qayee Biotechnology | 96T | EUR 361 |
|
Goat Tumor necrosis factor α,TNF-α ELISA KIT |
|||
| QY-E140007 | Qayee Biotechnology | 96T | EUR 413 |
 Sheep Tumor necrosis factor α（TNF-α）ELISA Kit |
|||
| QY-E140060 | Qayee Biotechnology | 96T | EUR 413 |
ELISA Kit) Mouse Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| QY-E21543 | Qayee Biotechnology | 96T | EUR 361 |
 Porcine tumor necrosis factor α,TNF-α ELISA Kit |
|||
| QY-E40006 | Qayee Biotechnology | 96T | EUR 394 |
ELISA Kit) Bovine Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| QY-E60007 | Qayee Biotechnology | 96T | EUR 426 |
 Canine Tumor necrosis factor α,TNF-α ELISA Kit |
|||
| QY-E70025 | Qayee Biotechnology | 96T | EUR 426 |
 Chicken Tumor necrosis factor α,TNF-α ELISA KIT |
|||
| QY-E80030 | Qayee Biotechnology | 96T | EUR 426 |
 TNF Alpha Monoclonal Antibody |
|||
| ABM40205-003ml | Abbkine | 0.03ml | EUR 158 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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|
TNF Alpha Monoclonal Antibody |
|||
| ABM40205-01ml | Abbkine | 0.1ml | EUR 289 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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|
TNF Alpha Monoclonal Antibody |
|||
| ABM40205-02ml | Abbkine | 0.2ml | EUR 414 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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|
TNF Alpha Monoclonal Antibody |
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| ABM40206-003ml | Abbkine | 0.03ml | EUR 158 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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|
TNF Alpha Monoclonal Antibody |
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| ABM40206-01ml | Abbkine | 0.1ml | EUR 289 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
|||
|
TNF Alpha Monoclonal Antibody |
|||
| ABM40206-02ml | Abbkine | 0.2ml | EUR 414 |
|
|||
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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 pAb rabbit anti-rat TNF-α |
|||
| CT062 | U-CyTech | 0.5 mg | EUR 184 |
 mAb mouse anti-human TNF-α |
|||
| CT258 | U-CyTech | 0.5 mg | EUR 260 |
|
mAb mouse anti-human TNF-α |
|||
| CT260 | U-CyTech | 0.5 mg | EUR 260 |
|
mAb mouse anti-human TNF-α |
|||
| CT271 | U-CyTech | 0.5 mg | EUR 260 |
) Recombinant mouse TNF-α (E.coli-derived) |
|||
| CT304 | U-CyTech | 10 µg | EUR 243 |
|
Recombinant mouse TNF-α (E.coli-derived) |
|||
| CT305 | U-CyTech | 100 µg | EUR 598 |
 pAb rabbit anti-mouse TNF-α |
|||
| CT315 | U-CyTech | 0.5 mg | EUR 184 |
, human (TFA)) TNF-α (31-45), human (TFA) |
|||
| HY-P1860A | MedChemExpress | 5mg | EUR 980 |
 Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit |
|||
| CN-00228G1 | ChemNorm | 96T | EUR 470 |
|
Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit |
|||
| CN-00228G2 | ChemNorm | 48T | EUR 320 |
ELISA Kit) Guinea pig Tumor necrosis factor α(TNF-α)ELISA Kit |
|||
| QY-E90069 | Qayee Biotechnology | 96T | EUR 478 |
 α-tubulin Mouse Monoclonal Antibody |
|||
| 37981-100ul | SAB | 100ul | EUR 252 |
|
α-tubulin Mouse Monoclonal Antibody |
|||
| 37981-50ul | SAB | 50ul | EUR 187 |
) HSP90 α Monoclonal antibody(1F6) |
|||
| 44076-100ul | SAB | 100ul | EUR 252 |
) HSP90 α Monoclonal antibody(7D6) |
|||
| 44078-100ul | SAB | 100ul | EUR 252 |
) Anti-Thioredoxin / TRX (6C10) |
|||
| YF-MA15994 | Abfrontier | 100 ug | EUR 363 |
|
Description: Mouse monoclonal to Thioredoxin / TRX |
|||
 Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-10ug | Novoprotein | 10ug | EUR 151 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
|||
|
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-1mg | Novoprotein | 1mg | EUR 1795 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
|||
|
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-500ug | Novoprotein | 500ug | EUR 1273 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
|||
|
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-50ug | Novoprotein | 50ug | EUR 344 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
|||
 Human IFN-γ / TNF-α FluoroSpot kit |
|||
| CT851-F2 | U-CyTech | 2-plate | EUR 579 |
 Monkey IFN-γ / TNF-α FluoroSpot kit |
|||
| CT901-F2 | U-CyTech | 2-plate | EUR 579 |
 17-α-hydoxy progesterone monoclonal antibody |
|||
| 10R-11483 | Fitzgerald | 1 mg | EUR 743 |
|
Description: Mouse anti-17-α-hydoxy progesterone monoclonal antibody |
|||
 pAb rabbit anti-rat TNF-α Biotin-labeled |
|||
| CT064 | U-CyTech | 0.5 mg | EUR 347 |
 pAb rabbit anti-mouse TNF-α Biotin labeled |
|||
| CT332 | U-CyTech | 0.5 mg | EUR 347 |
 Human TNF α converting enzyme,TACE ELISA Kit |
|||
| CN-03416H1 | ChemNorm | 96T | EUR 463 |
|
Human TNF α converting enzyme,TACE ELISA Kit |
|||
| CN-03416H2 | ChemNorm | 48T | EUR 312 |
ELISA Kit) Human TNF α converting enzyme(TACE)ELISA Kit |
|||
| GA-E0865HM-48T | GenAsia Biotech | 48T | EUR 289 |
|
Human TNF α converting enzyme(TACE)ELISA Kit |
|||
| GA-E0865HM-96T | GenAsia Biotech | 96T | EUR 466 |
|
Human TNF α converting enzyme(TACE)ELISA Kit |
|||
| QY-E00180 | Qayee Biotechnology | 96T | EUR 361 |
 Monoclonal TNF alpha Antibody, Clone: EP1085Y |
|||
| APR10496G | Leading Biology | 0.1ml | EUR 528 |
|
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB |
|||
 Mouse anti Canine TNF monoclonal antibody |
|||
| CABT-L129 | Creative Diagnostics | 500ug | EUR 819 |
 Mouse anti Rat TNF monoclonal antibody |
|||
| CABT-L378 | Creative Diagnostics | 100ug | EUR 715 |
 Mouse anti Porcine TNF monoclonal antibody |
|||
| CABT-L382 | Creative Diagnostics | 500ug | EUR 840 |
|
Mouse anti Porcine TNF monoclonal antibody |
|||
| CABT-L383 | Creative Diagnostics | 250 ug | EUR 892 |
 Monoclonal TNF-alpha Antibody, Clone: 2A9B9 |
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| APR13767G | Leading Biology | 0.1ml | EUR 484 |
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Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E |
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 TNF Receptor II recombinant monoclonal antibody |
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| A5046 | Bimake | 100ul X 3 | EUR 595 |
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Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA |
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) α tubulin Mouse Monoclonal Antibody(Zebrafish Specific) |
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| 38059-100ul | SAB | 100ul | EUR 252 |
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α tubulin Mouse Monoclonal Antibody(Zebrafish Specific) |
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| 38059-50ul | SAB | 50ul | EUR 187 |
 Monoclonal Antibody(5H5)) α-tubulin (Acetyl Lys40) Monoclonal Antibody(5H5) |
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| HW204-100ul | SAB | 100ul | EUR 252 |
 ELISA Kit) Canine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ECA0020 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 9.375pg/ml |
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 ELISA Kit) Bovine TNF-α(Tumor necrosis factor alpha) ELISA Kit |
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| EB0008 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 0.094 ng/ml |
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 ELISA Kit) Rat TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ER1393 | FN Test | 96T | EUR 476.25 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
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 ELISA Kit) Rabbit TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ERB0126 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml |
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 ELISA Kit) Sheep TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ESH0025 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml |
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 ELISA Kit) Monkey TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| EMK0079 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 18.75pg/ml |
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 ELISA Kit) Porcine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| EP0159 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml |
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 ELISA Kit) Camel Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit |
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| QY-E120067 | Qayee Biotechnology | 96T | EUR 478 |
 Mouse anti Guinea Pig TNF monoclonal antibody |
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| CABT-L155 | Creative Diagnostics | 500ug | EUR 819 |
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Mouse anti Guinea Pig TNF monoclonal antibody |
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| CABT-L156 | Creative Diagnostics | 250ug | EUR 881 |
 Rat anti Rhesus Macaque TNF monoclonal antibody |
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| CABT-L376 | Creative Diagnostics | 500ug | EUR 819 |
 Anti-TNF Receptor II Rabbit Monoclonal Antibody |
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| M01437 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal TNF Receptor II Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat. |
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) α Skeletal Muslce Actin Mouse Monoclonal Antibody(4B11) |
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| 38090-100ul | SAB | 100ul | EUR 252 |
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α Skeletal Muslce Actin Mouse Monoclonal Antibody(4B11) |
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| 38090-50ul | SAB | 50ul | EUR 187 |
 Monoclonal Antibody(4A8)(4A8)) α-tubulin (Acetyl Lys40) Monoclonal Antibody(4A8)(4A8) |
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| HW203-100ul | SAB | 100ul | EUR 252 |
 ELISA Kit) Guinea pig TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| EGP0049 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 9.375pg/ml |
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 TNF Antibody |
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| 35963-100ul | SAB | 100ul | EUR 252 |
 TNF antibody |
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| 38122-100ul | SAB | 100ul | EUR 252 |
 TNF ?? Antibody |
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| 39389-100ul | SAB | 100ul | EUR 390 |
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TNF Antibody |
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| 1-CSB-PA004310 | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000 |
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TNF Antibody |
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| 1-CSB-PA004963 | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
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TNF Antibody |
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| 1-CSB-PA07427A0Rb | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
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TNF Antibody |
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| 1-CSB-PA080266 | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:500-1:2000 |
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TNF Antibody |
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| 1-CSB-PA080267 | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:500-1:2000.IHC:1:50-1:200 |
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TNF Antibody |
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| 1-CSB-PA08474A0Rb | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Bovine. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000 |
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TNF Antibody |
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| CSB-PA147864- | Cusabio | EUR 335 | |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500 |
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TNF Antibody |
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| CSB-PA147864-100ul | Cusabio | 100ul | EUR 316 |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500 |
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TNF Antibody |
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| 1-CSB-PA954619 | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
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 TNF Antibody |
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| DF6080 | Affbiotech | 200ul | EUR 304 |
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Description: TNF Antibody detects endogenous levels of total TNF. |
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TNF Antibody |
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| 1-CSB-PA023955DA01SH | Cusabio |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Sheep. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000 |
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TNF Antibody |
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| CSB-PA023955KA01HU- | Cusabio | EUR 335 | |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100 |
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TNF Antibody |
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| CSB-PA023955KA01HU-100ul | Cusabio | 100ul | EUR 389 |
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Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100 |
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TNF Antibody |
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| ABD6080 | Lifescience Market | 100 ug | EUR 438 |
, Clone: 2C8) Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8 |
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| APR10497G | Leading Biology | 0.1mg | EUR 484 |
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Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P |
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 α-Internexin Antibody |
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| 21638-100ul | SAB | 100ul | EUR 252 |
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α-Internexin Antibody |
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| 21638-50ul | SAB | 50ul | EUR 187 |
 PDGFR α Antibody |
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| 33470-100ul | SAB | 100ul | EUR 252 |
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PDGFR α Antibody |
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| 33470-50ul | SAB | 50ul | EUR 187 |
 Tubulin α Antibody |
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| 33531-100ul | SAB | 100ul | EUR 252 |
Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion
Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.
Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness
A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
- We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
- Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
- Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
- Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
- Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.