plathlab

Using molecular dynamics simulations to prioritize and understand AI-generated

Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.

Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides

Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
plathlab
plathlab

TNF α Monoclonal Antibody(Q36)

E44H11101 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flotillin-1 Monoclonal Antibody(6C10)

E44H10807 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10

APR10588G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E

TNF α Mouse Monoclonal Antibody

E12-452 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TNF α Mouse Monoclonal Antibody

E12-453 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TNF α Mouse Monoclonal Antibody

EM1197-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

TNF α Mouse Monoclonal Antibody

EM1197-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10

AMM04145G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E

Flotillin Mouse Monoclonal Antibody(6C10)

38095 100ul
EUR 319

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-100ul 100ul
EUR 302.4

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-50ul 50ul
EUR 224.4

Flotillin-1 Mouse Monoclonal Antibody (6C10)

E038095 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody (6C10)

E12-197 100μg/100μlL
EUR 225
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody(6C10)

RA10006-100ul 100 ul
EUR 298

Flotillin-1 Mouse Monoclonal Antibody(6C10)

RA10006-50ul 50 ul
EUR 198

TNF α Mouse Monoclonal Antibody(Q34)

RA10029-100ul 100 ul
EUR 298

TNF α Mouse Monoclonal Antibody(Q34)

RA10029-50ul 50 ul
EUR 198

TNF α Mouse Monoclonal Antibody(Q36)

RA10030-100ul 100 ul
EUR 298

TNF α Mouse Monoclonal Antibody(Q36)

RA10030-50ul 50 ul
EUR 198

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100 100ul
EUR 319

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100-100ul 100ul
EUR 302.4

P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10)

E044100 100μg/100μl
EUR 255
Description: Available in various conjugation types.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

E44H11141 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha (TNF) mouse monoclonal antibody, clone 2C8

4T10-2C8 1 mg Ask for price

P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10)

RA10052-100ul 100 ul
EUR 298

P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10)

RA10052-50ul 50 ul
EUR 198

CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA802096 100 µl Ask for price

CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA802096S 30 µl Ask for price

GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA807139 100 µl Ask for price

GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA807139S 30 µl Ask for price

PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA803949 100 µl Ask for price

PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA803949S 30 µl Ask for price

ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA804173 100 µl Ask for price

ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA804173S 30 µl Ask for price

FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA503996 100 µl Ask for price

FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA503996S 30 µl Ask for price

Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529

CABT-Z181R 100 µg; 500 µg Ask for price
Description: Mouse

Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500838 100 µl Ask for price

Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500838S 30 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 2C8, Aff - Purified

AM26058PU-N 100 µg Ask for price

Biotinylated Mouse TNF-α Monoclonal Antibody, Rabbit MAb(DET)

RM98000 100μg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified

AM33351PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified

AM33351PU-T 20 µg Ask for price

Mouse Anti-Human TNF-α monoclonal antibody, clone C-G8

CABT-ZB421 200 µg
EUR 810
Description: Mouse

Mouse Anti-Human TNF-α monoclonal antibody, clone C-D8

CABT-ZB423 200 µg
EUR 810
Description: Mouse

P63-α Mouse Monoclonal Antibody (4C12)

E12-768 100μg/100μl
EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody(4C12)

RA10254-100ul 100 ul
EUR 298

P63-α Mouse Monoclonal Antibody(4C12)

RA10254-50ul 50 ul
EUR 198

Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500794 100 µl Ask for price

Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500794S 30 µl Ask for price

TNF alpha (TNF) (115-130) mouse monoclonal antibody, clone 4C6-H6, Supernatant

SM1330 2 ml Ask for price

Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8

APR10497G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P

Recombinant Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529S

CABT-Z180R 100 µg; 500 µg Ask for price
Description: Mouse

TNF Alpha Monoclonal Antibody

ABM40205-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF alpha Monoclonal Antibody

E-AB-22116-120uL 120uL
EUR 240
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-200uL 200uL
EUR 399
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-20uL 20uL
EUR 73
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-60uL 60uL
EUR 143
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-120uL 120uL
EUR 240
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-200uL 200uL
EUR 399
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-20uL 20uL
EUR 73
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-60uL 60uL
EUR 143
Description: Unconjugated

TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)

TA506513 100 µl Ask for price

TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)

TA506513S 30 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 1D9

4T10-1D9 1 mg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone F6C5

4T10-F6C5 1 mg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, Azide Free

PM1012A 500 µg Ask for price

TNF mouse monoclonal antibody, clone CC327, Purified

SM2216P 500 µg Ask for price

TNF alpha Mouse Monoclonal Antibody

E10G20443 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha Mouse Monoclonal Antibody

E10G20455 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha Mouse Monoclonal Antibody

E10G20462 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha (TNF) mouse monoclonal antibody, clone T1, FITC

AM26289FC-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B1E4, HRP

AM09183HR-N 200 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, PE

AM26711RP-N 100 Tests Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706, Purified

AM50317PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706, Purified

AM50317PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF655, Purified

AM50319PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF655, Purified

AM50319PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF656, Purified

AM50320PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF656, Purified

AM50320PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T3, Biotin

AM26288BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T1, Biotin

AM26289BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, APC

AM26711AC-N 100 Tests Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 52B83, FITC

AM26298FC-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, FITC

AM26711FC-N 100 Tests Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone tnfa9.9, Purified

AM02248PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone tnfa9.9, Purified

AM02248PU-S 10 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T1, Purified

AM32017PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T3, Purified

AM32018PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B1E4, Biotin

AM09183BT-N 100 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 195, Purified

AM05787PU-N 200 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 5N, Purified

AM26201PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T3, Purified

AM26288PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T1, Purified

AM26289PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B-D9, PE

AM31355RP-N 1 ml (100 Tests) Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 3.5F2, Purified

AM31996PU-N 100 µg Ask for price

Mouse anti Rat TNF monoclonal antibody

CABT-L378 100ug
EUR 858

TNF alpha (TNF) mouse monoclonal antibody, clone 4H31, Purified

AM32021PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone J1D9, Purified

AM32130PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab1, Purified

AM20447PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 4H31, Purified

AM26299PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B-D9, FITC

AM31355FC-N 1 ml (100 Tests) Ask for price

TNF alpha (TNF) rat monoclonal antibody, clone MP9-20A4, PE

SM1464R 100 Tests Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone J2D10, Purified

AM32129PU-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 52B83, Purified

AM32222PU-N 1 ml Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 2A9B9, Purified

AM06195PU-N 100 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 52B83, Purified

AM26298PU-N 100 µg Ask for price

Mouse anti TNF alpha Monoclonal Antibody

TA354418 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone SPM543, Purified

AM50176PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone SPM543, Purified

AM50176PU-T 20 µg Ask for price

Mouse Monoclonal Antibody to TNF-alpha

E10-20161 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to TNF-alpha

MAB-606020161 0.1mg
EUR 280

Mouse Monoclonal Antibody to TNF-alpha

sAP-0134 50ug
EUR 270

Mouse anti Canine TNF monoclonal antibody

CABT-L129 500ug
EUR 982.8

TNF alpha (TNF) mouse monoclonal antibody, clone #1, Azide Free

AM26466AF-N 100 µg Ask for price

Mouse anti Porcine TNF monoclonal antibody

CABT-L382 500ug
EUR 1008

Mouse anti Porcine TNF monoclonal antibody

CABT-L383 250 ug
EUR 1070.4

TNF alpha (TNF) mouse monoclonal antibody, clone P/T2, Purified

AM50316PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone P/T2, Purified

AM50316PU-T 20 µg Ask for price

Carrier-free (BSA/glycerol-free) CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF802096 100 µg Ask for price

Carrier-free (glycerol/BSA-free) GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF807139 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab1, Azide Free

AM20447AF-N 100 µg Ask for price

α-SMA Monoclonal Antibody

40482 100ul
EUR 319

α-SMA Monoclonal Antibody

40482-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40482-50ul 50ul
EUR 224.4

α-SMA Monoclonal Antibody

40495-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40495-50ul 50ul
EUR 224.4

α-SMA Monoclonal Antibody

E040482 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E040495 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E20-53364 100ug
EUR 225
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E20-53365 100ug
EUR 225
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

ABM0052-100uL 100 μL
EUR 229
Description: Mouse Anti-α-SMA Monoclonal Antibody

Carrier-free (BSA/glycerol-free) FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF503996 100 µg Ask for price

Carrier-free (BSA/glycerol-free) LEMD3 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF500794 100 µg Ask for price

Carrier-free (BSA/glycerol-free) ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF500838 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF803949 100 µg Ask for price

Carrier-free (BSA/glycerol-free) ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF804173 100 µg Ask for price

HSP90 α Monoclonal Antibody

E20-53480 100ug
EUR 225
Description: Available in various conjugation types.

HSP90 α Monoclonal Antibody

E20-53496 100ug
EUR 225
Description: Available in various conjugation types.

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706 + P/T2, Purified

AM50318PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706 + P/T2, Purified

AM50318PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B1E4, Aff - Purified

AM09183PU-N 500 µg Ask for price

TNF alpha (TNF) rat monoclonal antibody, clone MP9-20A4, Purified

SM1464P 500 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T1, Biotin, Purified

AM32017BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T3, Biotin, Purified

AM32018BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, Aff - Purified

AM26711PU-N 100 µg Ask for price

TNF alpha (TNF) rat monoclonal antibody, clone GMO1-17A2, Purified

AM01290PU-N 500 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone CH8820, Aff - Purified

DM1049 500 µg Ask for price

α-tubulin Monoclonal Antibody

E20-53035 100ug
EUR 225
Description: Available in various conjugation types.

α-tubulin Monoclonal Antibody

E20-53115 100ug
EUR 225
Description: Available in various conjugation types.

α-tubulin Monoclonal Antibody

E44H10765 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha (TNF) mouse monoclonal antibody, clone B-C7, Azide Free

AM31354AF-N 500 µg Ask for price

TNF Receptor II recombinant monoclonal antibody

A5046 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA

Rat Monoclonal anti-Mouse TNF-a Antibody

xAP-0832 100ug
EUR 280

Rat Monoclonal anti-Mouse TNF-a Antibody

xAP-0833 100ug
EUR 280

TNF alpha (TNF) rat monoclonal antibody, clone MP9-20A4, Azide Free

SM1464A 1 mg Ask for price

TNF alpha (TNF) (1-234) mouse monoclonal antibody, clone M1-C4, Purified

AM31768PU-N 50 µg Ask for price

Mouse anti Guinea Pig TNF monoclonal antibody

CABT-L155 500ug
EUR 982.8

Mouse anti Guinea Pig TNF monoclonal antibody

CABT-L156 250ug
EUR 1057.2

Mouse Monoclonal anti-Human TNF-a Antibody

xAP-0466 100ug
EUR 280

Mouse Monoclonal anti-Human TNF-a Antibody

xAP-0467 100ug
EUR 280

Rat anti Rhesus Macaque TNF monoclonal antibody

CABT-L376 500ug
EUR 982.8

Monoclonal TNF alpha Antibody, Clone: EP1085Y

APR10496G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB

Monoclonal TNF-alpha Antibody, Clone: 2A9B9

APR13767G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E

Monoclonal Anti- α-hCG Antibody.

TMH011-0.25mg 0.25mg
EUR 169
Description: Isotype: IgG1. This antibody can be paired with THM014, and THM016 for hCG detection.

Monoclonal Anti- α-hCG Antibody.

TMH011-1mg 1mg
EUR 569
Description: Isotype: IgG1. This antibody can be paired with THM014, and THM016 for hCG detection.

HSP90 α Monoclonal antibody(1F6)

44076 100ul
EUR 319

HSP90 α Monoclonal antibody(1F6)

44076-100ul 100ul
EUR 302.4

HSP90 α Monoclonal antibody(7D6)

44078 100ul
EUR 319

HSP90 α Monoclonal antibody(7D6)

44078-100ul 100ul
EUR 302.4

HSP90 α Monoclonal antibody (1F6)

E044076 100μg/100μl
EUR 255
Description: Available in various conjugation types.

HSP90 α Monoclonal antibody (7D6)

E044078 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody(1E12)

E44H10987 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

α-SMA Monoclonal Antibody(6A12)

E44H10988 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HSP90 α Monoclonal Antibody(1F6)

E44H11103 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HSP90 α Monoclonal Antibody(7D6)

E44H11119 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Tubulin α (9H4) monoclonal antibody

E43B8025 100ul
EUR 225
Description: Available in various conjugation types.

HSP90 α Mouse Monoclonal Antibody

EM1199-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against HSP90 ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

HSP90 α Mouse Monoclonal Antibody

EM1199-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against HSP90 ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Mouse Monoclonal anti-Human LT-a (TNF-ß) Antibody

xAP-0444 100ug
EUR 280

α-tubulin Monoclonal Antibody(8F11)

E44H10685 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF mouse monoclonal antibody, clone 4F4, Azide Free

SM2085A 500 µg Ask for price

α-tubulin Mouse Monoclonal Antibody

37981 100ul
EUR 319

α-tubulin Mouse Monoclonal Antibody

37981-100ul 100ul
EUR 302.4

α-tubulin Mouse Monoclonal Antibody

37981-50ul 50ul
EUR 224.4

α-tubulin Mouse Monoclonal Antibody

E037981 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-tubulin Mouse Monoclonal Antibody

E12-048 100μg/100μl
EUR 150
Description: Available in various conjugation types.

α-tubulin Mouse Monoclonal Antibody

E12-049 100μg/100μl
EUR 225
Description: Available in various conjugation types.

α-tubulin Mouse Monoclonal Antibody

EM1034-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against ?-tubulin from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, IP

α-tubulin Mouse Monoclonal Antibody

EM1034-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against ?-tubulin from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, IP

Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion

Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.

Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness

A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
  • We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
  • Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
  • Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
  • Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
  • Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.

 

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