Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.
Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides
Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
TNF-α Polyclonal Antibody |
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| A71438-100 | EpiGentek | 100 ul | EUR 423.5 |
Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10 |
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| AMM04145G | Leading Biology | 0.05mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E |
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Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10 |
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| APR10588G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E |
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Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-100ul | SAB | 100ul | EUR 302.4 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-50ul | SAB | 50ul | EUR 224.4 |
TNF-α Rabbit pAb |
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| A0277-100ul | Abclonal | 100 ul | EUR 369.6 |
TNF-α Rabbit pAb |
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| A0277-200ul | Abclonal | 200 ul | EUR 550.8 |
TNF-α Rabbit pAb |
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| A0277-20ul | Abclonal | 20 ul | EUR 219.6 |
TNF-α Rabbit pAb |
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| A0277-50ul | Abclonal | 50 ul | EUR 267.6 |
TNF-α Rabbit pAb |
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| A11534-100ul | Abclonal | 100 ul | EUR 369.6 |
TNF-α Rabbit pAb |
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| A11534-200ul | Abclonal | 200 ul | EUR 550.8 |
TNF-α Rabbit pAb |
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| A11534-20ul | Abclonal | 20 ul | EUR 219.6 |
TNF-α Rabbit pAb |
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| A11534-50ul | Abclonal | 50 ul | EUR 267.6 |
TNF-α, His, Human |
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| HY-P7416 | MedChemExpress | 50ug | EUR 362.4 |
TNF-α, His, Mouse |
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| HY-P7417 | MedChemExpress | 50ug | EUR 583.2 |
Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative |
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| 100-210-TNF | Alpha Diagnostics | 1 kit | EUR 578.4 |
Marmoset TNF-α ELISPOT antibody pair |
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| CT962-10 | U-CyTech | 10-plate | EUR 633.6 |
Marmoset TNF-α ELISPOT antibody pair |
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| CT962-20 | U-CyTech | 20-plate | EUR 1107.6 |
Monkey TNF-α ELISPOT antibody pair |
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| CT617-10 | U-CyTech | 10-plate | EUR 633.6 |
Monkey TNF-α ELISPOT antibody pair |
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| CT617-20 | U-CyTech | 20-plate | EUR 1107.6 |
Human TNF-α ELISPOT antibody pair |
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| CT647-10 | U-CyTech | 10-plate | EUR 633.6 |
Human TNF-α ELISPOT antibody pair |
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| CT647-20 | U-CyTech | 20-plate | EUR 1107.6 |
Mouse TNF-α ELISPOT antibody pair |
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| CT661-10 | U-CyTech | 10-plate | EUR 633.6 |
Mouse TNF-α ELISPOT antibody pair |
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| CT661-20 | U-CyTech | 20-plate | EUR 1107.6 |
Rat TNF-α ELISA antibody pair |
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| CT704-10 | U-CyTech | 10-plate | EUR 656.4 |
Rat TNF-α ELISA antibody pair |
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| CT704-20 | U-CyTech | 20-plate | EUR 1118.4 |
Monkey TNF-α ELISA antibody pair |
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| CT717-10 | U-CyTech | 10-plate | EUR 656.4 |
Monkey TNF-α ELISA antibody pair |
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| CT717-20 | U-CyTech | 20-plate | EUR 1118.4 |
Human TNF-α ELISA antibody pair |
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| CT747-10 | U-CyTech | 10-plate | EUR 656.4 |
Human TNF-α ELISA antibody pair |
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| CT747-20 | U-CyTech | 20-plate | EUR 1118.4 |
Mouse TNF-α ELISA antibody pair |
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| CT761-10 | U-CyTech | 10-plate | EUR 656.4 |
Mouse TNF-α ELISA antibody pair |
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| CT761-20 | U-CyTech | 20-plate | EUR 1118.4 |
Marmoset TNF-α ELISA antibody pair |
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| CT772-10 | U-CyTech | 10-plate | EUR 656.4 |
Marmoset TNF-α ELISA antibody pair |
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| CT772-20 | U-CyTech | 20-plate | EUR 1118.4 |
TNF ? Monoclonal Antibody |
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| EM1197-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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TNF ? Monoclonal Antibody |
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| EM1197-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| 44100-100ul | SAB | 100ul | EUR 302.4 |
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-10ug | Novoprotein | 10ug | EUR 201.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Recombinant Rabbit Tumor Necrosis Factor α/TNF-α |
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| C082-50ug | Novoprotein | 50ug | EUR 486 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
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Swine TNF-α ELISA Kit |
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| DEIA-T6108 | Creative Diagnostics | 96T | EUR 639.6 |
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Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product. |
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Mouse TNF-α ELISA kit |
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| DEIA7391 | Creative Diagnostics | 96T | EUR 889.2 |
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Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support. |
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Marmoset TNF-α ELISPOT kit |
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| CT938-PR2 | U-CyTech | 2-plate | EUR 498 |
Marmoset TNF-α ELISPOT kit |
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| CT938-PR5 | U-CyTech | 5-plate | EUR 667.2 |
Rat TNF-α ELISA kit |
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| CT075A | U-CyTech | 5-plate | EUR 554.4 |
Monkey TNF-α ELISPOT kit |
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| CT133-PB2 | U-CyTech | 2-plate | EUR 498 |
Monkey TNF-α ELISPOT kit |
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| CT133-PB5 | U-CyTech | 5-plate | EUR 681.6 |
Monkey TNF-α ELISPOT kit |
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| CT133-PR2 | U-CyTech | 2-plate | EUR 498 |
Monkey TNF-α ELISPOT kit |
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| CT133-PR5 | U-CyTech | 5-plate | EUR 667.2 |
Monkey TNF-α ELISPOT kit |
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| CT133-T2 | U-CyTech | 2-plate | EUR 432 |
Monkey TNF-α ELISPOT kit |
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| CT133-T5 | U-CyTech | 5-plate | EUR 694.8 |
Monkey TNF-α ELISA kit |
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| CT148A | U-CyTech | 5-plate | EUR 554.4 |
Human TNF-α ELISA kit |
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| CT209A | U-CyTech | 5-plate | EUR 554.4 |
Human TNF-α ELISPOT kit |
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| CT237-PB2 | U-CyTech | 2-plate | EUR 498 |
Human TNF-α ELISPOT kit |
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| CT237-PB5 | U-CyTech | 5-plate | EUR 681.6 |
Human TNF-α ELISPOT kit |
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| CT237-PR2 | U-CyTech | 2-plate | EUR 498 |
Human TNF-α ELISPOT kit |
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| CT237-PR5 | U-CyTech | 5-plate | EUR 667.2 |
Human TNF-α ELISPOT kit |
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| CT237-T2 | U-CyTech | 2-plate | EUR 432 |
Human TNF-α ELISPOT kit |
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| CT237-T5 | U-CyTech | 5-plate | EUR 694.8 |
Mouse TNF-α ELISA kit |
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| CT303A | U-CyTech | 5-plate | EUR 554.4 |
Mouse TNF-α ELISPOT kit |
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| CT322-PB2 | U-CyTech | 2-plate | EUR 498 |
Mouse TNF-α ELISPOT kit |
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| CT322-PB5 | U-CyTech | 5-plate | EUR 681.6 |
Mouse TNF-α ELISPOT kit |
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| CT322-PR2 | U-CyTech | 2-plate | EUR 498 |
Mouse TNF-α ELISPOT kit |
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| CT322-PR5 | U-CyTech | 5-plate | EUR 667.2 |
Mouse TNF-α ELISPOT kit |
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| CT322-T2 | U-CyTech | 2-plate | EUR 432 |
Mouse TNF-α ELISPOT kit |
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| CT322-T5 | U-CyTech | 5-plate | EUR 694.8 |
Marmoset TNF-α ELISA kit |
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| CT342A | U-CyTech | 5-plate | EUR 554.4 |
human TNF-α，His tag |
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| E410A13-10 | EnoGene | 100μg | EUR 832.8 |
TNF-α (31-45), human |
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| HY-P1860 | MedChemExpress | 1mg | EUR 432 |
Recombinant Mouse TNF α Protein |
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| RP00816 | Abclonal | 10 μg | EUR 219.6 |
α-SMA Monoclonal Antibody |
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| 40482-100ul | SAB | 100ul | EUR 302.4 |
α-SMA Monoclonal Antibody |
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| 40482-50ul | SAB | 50ul | EUR 224.4 |
α-SMA Monoclonal Antibody |
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| 40495-100ul | SAB | 100ul | EUR 302.4 |
α-SMA Monoclonal Antibody |
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| 40495-50ul | SAB | 50ul | EUR 224.4 |
Anti-TNF-α (Golimumab), Human IgG1 Antibody |
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| A2141-100 | Biovision | 100 µg | EUR 612 |
Anti-TNF-α (Certolizumab Pegol), Humanized Antibody |
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| A2142-100 | Biovision | 100 µg | EUR 612 |
Genorise® Sheep TNF-α polyclonal antibody |
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| GR130002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Mouse TNF-α polyclonal antibody |
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| GR131002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Rat TNF-α polyclonal antibody |
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| GR132002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Rabbit TNF-α Polyclonal antibody |
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| GR180018 | Genorise Scientific | 100 mg | EUR 477.6 |
Genorise® Monkey TNF-α Polyclonal antibody |
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| GR184062 | Genorise Scientific | 100 mg | EUR 477.6 |
Genorise® Hamster TNF-α polyclonal antibody |
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| GR208002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Feline TNF-α polyclonal antibody |
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| GR195002 | Genorise Scientific | 100 µg | EUR 477.6 |
Goat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-00367S1 | ChemNorm | 96T | EUR 548.4 |
Goat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-00367S2 | ChemNorm | 48T | EUR 367.2 |
PoFAine tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-01217P1 | ChemNorm | 96T | EUR 564 |
PoFAine tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-01217P2 | ChemNorm | 48T | EUR 384 |
Rat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-01587R1 | ChemNorm | 96T | EUR 530.4 |
Rat Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-01587R2 | ChemNorm | 48T | EUR 351.6 |
Human Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-03277H1 | ChemNorm | 96T | EUR 542.4 |
Human Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-03277H2 | ChemNorm | 48T | EUR 362.4 |
Monkey Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02231M1 | ChemNorm | 96T | EUR 592.8 |
Monkey Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02231M2 | ChemNorm | 48T | EUR 412.8 |
Mouse Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02415M1 | ChemNorm | 96T | EUR 548.4 |
Mouse Tumor necrosis factor α,TNF-α ELISA KIT |
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| CN-02415M2 | ChemNorm | 48T | EUR 367.2 |
Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit |
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| EHA0004 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 1.875pg/ml |
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Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
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| GA-E0772RT-48T | GenAsia Biotech | 48T | EUR 380.4 |
Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
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| GA-E0772RT-96T | GenAsia Biotech | 96T | EUR 595.2 |
Bovine tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0017BV-48T | GenAsia Biotech | 48T | EUR 403.2 |
Bovine tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0017BV-96T | GenAsia Biotech | 96T | EUR 640.8 |
Human Tumor necrosis factor α(TNF-α)ELISA Kit |
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| GA-E0122HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Tumor necrosis factor α(TNF-α)ELISA Kit |
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| GA-E0122HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0130MS-48T | GenAsia Biotech | 48T | EUR 403.2 |
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT |
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| GA-E0130MS-96T | GenAsia Biotech | 96T | EUR 640.8 |
Chicken Tumor necrosis factor α,TNF-α ELISA KIT |
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| QY-E80030 | Qayee Biotechnology | 96T | EUR 511.2 |
Human Tumor necrosis factor α(TNF-α)ELISA Kit |
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| QY-E00182 | Qayee Biotechnology | 96T | EUR 433.2 |
Rat Tumor necrosis factor α(TNF-α)ELISA Kit |
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| QY-E10880 | Qayee Biotechnology | 96T | EUR 433.2 |
Goat Tumor necrosis factor α,TNF-α ELISA KIT |
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| QY-E140007 | Qayee Biotechnology | 96T | EUR 495.6 |
Sheep Tumor necrosis factor α（TNF-α）ELISA Kit |
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| QY-E140060 | Qayee Biotechnology | 96T | EUR 495.6 |
Mouse Tumor necrosis factor α(TNF-α)ELISA Kit |
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| QY-E21543 | Qayee Biotechnology | 96T | EUR 433.2 |
Porcine tumor necrosis factor α,TNF-α ELISA Kit |
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| QY-E40006 | Qayee Biotechnology | 96T | EUR 472.8 |
Bovine Tumor necrosis factor α(TNF-α)ELISA Kit |
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| QY-E60007 | Qayee Biotechnology | 96T | EUR 511.2 |
Canine Tumor necrosis factor α,TNF-α ELISA Kit |
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| QY-E70025 | Qayee Biotechnology | 96T | EUR 511.2 |
anti-STAT6 (6C10) |
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| LF-MA10315 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse monoclonal to STAT6 |
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Anti-STAT6 (6C10) |
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| YF-MA15643 | Abfrontier | 200 ul | EUR 435.6 |
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Description: Mouse monoclonal to STAT6 |
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Anti-BRD3 (6C10) |
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| YF-MA16265 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse monoclonal to BRD3 |
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Anti-BRD3 (6C10) |
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| YF-MA16266 | Abfrontier | 200 ul | EUR 435.6 |
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Description: Mouse monoclonal to BRD3 |
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pAb rabbit anti-rat TNF-α |
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| CT062 | U-CyTech | 0.5 mg | EUR 220.8 |
mAb mouse anti-human TNF-α |
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| CT258 | U-CyTech | 0.5 mg | EUR 312 |
mAb mouse anti-human TNF-α |
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| CT260 | U-CyTech | 0.5 mg | EUR 312 |
mAb mouse anti-human TNF-α |
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| CT271 | U-CyTech | 0.5 mg | EUR 312 |
Recombinant mouse TNF-α (E.coli-derived) |
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| CT304 | U-CyTech | 10 µg | EUR 291.6 |
Recombinant mouse TNF-α (E.coli-derived) |
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| CT305 | U-CyTech | 100 µg | EUR 717.6 |
pAb rabbit anti-mouse TNF-α |
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| CT315 | U-CyTech | 0.5 mg | EUR 220.8 |
TNF-α (31-45), human (TFA) |
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| HY-P1860A | MedChemExpress | 5mg | EUR 1176 |
TNF Alpha Monoclonal Antibody |
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| ABM40205-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40205-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40205-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40206-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40206-01ml | Abbkine | 0.1ml | EUR 346.8 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40206-02ml | Abbkine | 0.2ml | EUR 496.8 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-00228G1 | ChemNorm | 96T | EUR 564 |
Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit |
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| CN-00228G2 | ChemNorm | 48T | EUR 384 |
Guinea pig Tumor necrosis factor α(TNF-α)ELISA Kit |
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| QY-E90069 | Qayee Biotechnology | 96T | EUR 573.6 |
Genorise® Guinea Pig TNF-α polyclonal antibody |
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| GR174002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Biotinylated Hamster TNF-α polyclonal antibody |
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| GR209002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Biotinylated Rabbit TNF-α Polyclonal antibody |
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| GR191018 | Genorise Scientific | 50 mg | EUR 477.6 |
Genorise® Biotinylated Feline TNF-α polyclonal antibody |
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| GR196002 | Genorise Scientific | 100 µg | EUR 477.6 |
Genorise® Biotinylated Monkey TNF-α Polyclonal antibody |
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| GR197014 | Genorise Scientific | 100 mg | EUR 477.6 |
HSP90 α Monoclonal antibody(1F6) |
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| 44076-100ul | SAB | 100ul | EUR 302.4 |
HSP90 α Monoclonal antibody(7D6) |
|||
| 44078-100ul | SAB | 100ul | EUR 302.4 |
α-tubulin Mouse Monoclonal Antibody |
|||
| 37981-100ul | SAB | 100ul | EUR 302.4 |
α-tubulin Mouse Monoclonal Antibody |
|||
| 37981-50ul | SAB | 50ul | EUR 224.4 |
Anti-Thioredoxin / TRX (6C10) |
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| YF-MA15994 | Abfrontier | 100 ug | EUR 435.6 |
|
Description: Mouse monoclonal to Thioredoxin / TRX |
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Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-10ug | Novoprotein | 10ug | EUR 181.2 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
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| C036-1mg | Novoprotein | 1mg | EUR 2154 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-500ug | Novoprotein | 500ug | EUR 1527.6 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant |
|||
| C036-50ug | Novoprotein | 50ug | EUR 412.8 |
|
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Human IFN-γ / TNF-α FluoroSpot kit |
|||
| CT851-F2 | U-CyTech | 2-plate | EUR 694.8 |
Monkey IFN-γ / TNF-α FluoroSpot kit |
|||
| CT901-F2 | U-CyTech | 2-plate | EUR 694.8 |
Genorise® Recombinant Rat TNF-α protein |
|||
| GR125003 | Genorise Scientific | 5 µg | EUR 342 |
Genorise® Chicken TNF-α Expression Plasmid |
|||
| GR148005 | Genorise Scientific | 10 µg | EUR 262.8 |
Nori® duck TNF-α ELISA Kit |
|||
| GR149025 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Hamster TNF-α ELISA Kit |
|||
| GR172146 | Genorise Scientific | 96-well | EUR 553.2 |
Genorise® Recombinant turkey TNF-α protein |
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| GR185003 | Genorise Scientific | 5 mg | EUR 342 |
Nori® Turkey TNF-α ELISA Kit |
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| GR187025 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Feline TNF-α ELISA Kit |
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| GR188146 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Ferret TNF-α ELISA Kit |
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| GR201055 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Salmon TNF-α ELISA Kit |
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| GR202055 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Zebrafish TNF-α ELISA Kit |
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| GR206055 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Ovine TNF-α DyLight 488 Polyclonal Antibody |
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| GR203001 | Genorise Scientific | 50 µg | EUR 477.6 |
17-α-hydoxy progesterone monoclonal antibody |
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| 10R-11483 | Fitzgerald | 1 mg | EUR 891.6 |
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Description: Mouse anti-17-α-hydoxy progesterone monoclonal antibody |
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Human TNF α converting enzyme,TACE ELISA Kit |
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| CN-03416H1 | ChemNorm | 96T | EUR 555.6 |
Human TNF α converting enzyme,TACE ELISA Kit |
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| CN-03416H2 | ChemNorm | 48T | EUR 374.4 |
pAb rabbit anti-rat TNF-α Biotin-labeled |
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| CT064 | U-CyTech | 0.5 mg | EUR 416.4 |
pAb rabbit anti-mouse TNF-α Biotin labeled |
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| CT332 | U-CyTech | 0.5 mg | EUR 416.4 |
Human TNF α converting enzyme(TACE)ELISA Kit |
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| GA-E0865HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human TNF α converting enzyme(TACE)ELISA Kit |
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| GA-E0865HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human TNF α converting enzyme(TACE)ELISA Kit |
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| QY-E00180 | Qayee Biotechnology | 96T | EUR 433.2 |
TNF Receptor II recombinant monoclonal antibody |
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| A5046 | Bimake | 100ul X 3 | EUR 714 |
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Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA |
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Monoclonal TNF-alpha Antibody, Clone: 2A9B9 |
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| APR13767G | Leading Biology | 0.1ml | EUR 580.8 |
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Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E |
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Monoclonal TNF alpha Antibody, Clone: EP1085Y |
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| APR10496G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB |
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Mouse anti Canine TNF monoclonal antibody |
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| CABT-L129 | Creative Diagnostics | 500ug | EUR 982.8 |
Mouse anti Rat TNF monoclonal antibody |
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| CABT-L378 | Creative Diagnostics | 100ug | EUR 858 |
Mouse anti Porcine TNF monoclonal antibody |
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| CABT-L382 | Creative Diagnostics | 500ug | EUR 1008 |
Mouse anti Porcine TNF monoclonal antibody |
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| CABT-L383 | Creative Diagnostics | 250 ug | EUR 1070.4 |
α tubulin Mouse Monoclonal Antibody(Zebrafish Specific) |
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| 38059-100ul | SAB | 100ul | EUR 302.4 |
α tubulin Mouse Monoclonal Antibody(Zebrafish Specific) |
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| 38059-50ul | SAB | 50ul | EUR 224.4 |
α-tubulin (Acetyl Lys40) Monoclonal Antibody(5H5) |
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| HW204-100ul | SAB | 100ul | EUR 302.4 |
Recombinant Human Tumor Necrosis Factor-alpha (rHu TNF-α) |
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| AK9887-0025 | Akron Biotech | 25µg | EUR 840 |
Recombinant Human Tumor Necrosis Factor-alpha (rHu TNF-α) |
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| AK9887-0050 | Akron Biotech | 50µg | EUR 1320 |
Rat TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ER1393 | FN Test | 96T | EUR 571.5 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
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Rabbit TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ERB0126 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml |
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Porcine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| EP0159 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml |
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Canine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ECA0020 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 9.375pg/ml |
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Bovine TNF-α(Tumor necrosis factor alpha) ELISA Kit |
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| EB0008 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 0.094 ng/ml |
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Sheep TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit |
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| ESH0025 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml |
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Nori® Equine TNF-β/Lymphotoxin-α ELISA Kit |
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| GR106637 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Bovine TNF-β/Lymphotoxin-α ELISA Kit |
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| GR112086 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Porcine TNF-β/Lymphotoxin-α ELISA Kit |
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| GR113238 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Canine TNF-β/Lymphotoxin-α ELISA Kit |
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| GR115137 | Genorise Scientific | 96-well | EUR 553.2 |
Nori® Ovine TNF-β/Lymphotoxin-α ELISA Kit |
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| GR116039 | Genorise Scientific | 96-well | EUR 553.2 |
Camel Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit |
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| QY-E120067 | Qayee Biotechnology | 96T | EUR 573.6 |
Mouse anti Guinea Pig TNF monoclonal antibody |
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| CABT-L155 | Creative Diagnostics | 500ug | EUR 982.8 |
Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion
Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.
Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness
A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
- We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
- Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
- Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
- Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
- Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.