Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.
Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides
Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
TNF α Monoclonal antibody(Q36) |
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| 44074-100ul | SAB | 100ul | EUR 302.4 |
TNF α Monoclonal antibody(Q34) |
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| E044073 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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TNF α Monoclonal antibody(Q36) |
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| E044074 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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TNF α Monoclonal Antibody(Q34) |
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| E44H11100 | EnoGene | 100ul | EUR 255 |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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TNF α Monoclonal Antibody(Q36) |
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| E44H11101 | EnoGene | 100ul | EUR 255 |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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TNF α Mouse Monoclonal Antibody |
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| EM1197-100ul | ELK Biotech | 100ul | EUR 124 |
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Description: WB, IHC |
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TNF α Mouse Monoclonal Antibody |
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| EM1197-50ul | ELK Biotech | 50ul | EUR 74 |
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Description: WB, IHC |
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TNF α Mouse Monoclonal Antibody |
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| E12-452 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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TNF α Mouse Monoclonal Antibody |
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| E12-453 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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Flotillin-1 Monoclonal Antibody(6C10) |
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| BT-MCA0561-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
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Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. |
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Flotillin-1 Monoclonal Antibody(6C10) |
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| BT-MCA0561-20ul | Jiaxing Korain Biotech Ltd (BT Labs) | 20ul | Ask for price |
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Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. |
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Flotillin-1 Monoclonal Antibody(6C10) |
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| BT-MCA0561-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
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Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. |
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Flotillin-1 Monoclonal Antibody(6C10) |
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| JOT-MCA0561-100ul | Jotbody | 100ul | EUR 220 |
Flotillin-1 Monoclonal Antibody(6C10) |
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| JOT-MCA0561-50ul | Jotbody | 50ul | EUR 144 |
Flotillin-1 Monoclonal Antibody(6C10) |
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| E44H10807 | EnoGene | 100ul | EUR 255 |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Flotillin-1 Monoclonal Antibody (6C10) |
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| MBS9241481-01mL | MyBiosource | 0.1mL | EUR 425 |
Flotillin-1 Monoclonal Antibody (6C10) |
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| MBS9241481-5x01mL | MyBiosource | 5x0.1mL | EUR 1887 |
Flotillin-1 Monoclonal Antibody(6C10) |
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| UB-GEN-16266 | UpingBio | 100 ul | EUR 200 |
Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10 |
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| APR10588G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E |
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Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10 |
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| AMM04145G | Leading Biology | 0.05mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E |
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Flotillin Mouse Monoclonal Antibody(6C10) |
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| 38095 | SAB | 100ul | EUR 319 |
STAT1 Recombinant Monoclonal Antibody [6C10] |
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| A73753 | EpiGentek | 50 µl | EUR 299 |
CD4 Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M15353 | EnoGene | 100 ug | EUR 595 |
CD4 Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M15353V-2 | EnoGene | 50 ul | EUR 195 |
GFI1 Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M17638 | EnoGene | 100 ug | EUR 595 |
GFI1 Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M17638V-2 | EnoGene | 50 ul | EUR 195 |
RAD21 Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M20125 | EnoGene | 100 ug | EUR 595 |
RAD21 Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M20125V-2 | EnoGene | 50 ul | EUR 195 |
PTCH1 Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M16223 | EnoGene | 100 ug | EUR 595 |
PTCH1 Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M16223V-2 | EnoGene | 50 ul | EUR 195 |
TNF α Mouse Monoclonal Antibody(Q34) |
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| RA10029-100ul | Reed Biotech | 100 ul | EUR 298 |
TNF α Mouse Monoclonal Antibody(Q34) |
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| RA10029-50ul | Reed Biotech | 50 ul | EUR 198 |
TNF α Mouse Monoclonal Antibody(Q36) |
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| RA10030-100ul | Reed Biotech | 100 ul | EUR 298 |
TNF α Mouse Monoclonal Antibody(Q36) |
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| RA10030-50ul | Reed Biotech | 50 ul | EUR 198 |
FBXO21 Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M12098V-2 | EnoGene | 50 ul | EUR 195 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-100ul | SAB | 100ul | EUR 302.4 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| 38095-50ul | SAB | 50ul | EUR 224.4 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| E038095 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| E12-197 | EnoGene | 100μg/100μlL | EUR 225 |
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Description: Available in various conjugation types. |
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ATP5F1B Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M09475V-2 | EnoGene | 50 ul | EUR 195 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| MBS9400280-01mL | MyBiosource | 0.1mL | EUR 305 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| MBS9400280-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
Flotillin-1 Mouse Monoclonal Antibody (6C10) |
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| MBS8500304-01mg | MyBiosource | 0.1mg | EUR 305 |
Flotillin-1 Mouse Monoclonal Antibody (6C10) |
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| MBS8500304-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
Flotillin-1 Mouse Monoclonal Antibody (6C10) |
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| MBS8500304-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
Flotillin-1 Mouse Monoclonal Antibody (6C10) |
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| MBS8500304-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
Flotillin-1 Mouse Monoclonal Antibody (6C10) |
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| MBS8500304-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| RA10006-100ul | Reed Biotech | 100 ul | EUR 298 |
Flotillin-1 Mouse Monoclonal Antibody(6C10) |
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| RA10006-50ul | Reed Biotech | 50 ul | EUR 198 |
MAN1 (LEMD3) Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M09432V-2 | EnoGene | 50 ul | EUR 195 |
C10orf63 (ENKUR) Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M16337 | EnoGene | 100 ug | EUR 595 |
C10orf63 (ENKUR) Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M16337V-2 | EnoGene | 50 ul | EUR 195 |
MSL2L1 (MSL2) Mouse Monoclonal Antibody [Clone:6C10] |
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| E45M20093 | EnoGene | 100 ug | EUR 595 |
MSL2L1 (MSL2) Mouse Monoclonal Antibody [Clone 6C10] |
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| E45M20093V-2 | EnoGene | 50 ul | EUR 195 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| 44100 | SAB | 100ul | EUR 319 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| 44100-100ul | SAB | 100ul | EUR 302.4 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| BT-MCA0974-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
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Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| BT-MCA0974-20ul | Jiaxing Korain Biotech Ltd (BT Labs) | 20ul | Ask for price |
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Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| BT-MCA0974-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
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Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| JOT-MCA0974-100ul | Jotbody | 100ul | EUR 220 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| JOT-MCA0974-50ul | Jotbody | 50ul | EUR 144 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
|||
| E044100 | EnoGene | 100μg/100μl | EUR 255 |
|
Description: Available in various conjugation types. |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| E44H11141 | EnoGene | 100ul | EUR 255 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10) |
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| MBS9241705-01mL | MyBiosource | 0.1mL | EUR 425 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10) |
|||
| MBS9241705-5x01mL | MyBiosource | 5x0.1mL | EUR 1887 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
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| MBS9417501-005mL | MyBiosource | 0.05mL | EUR 245 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
|||
| MBS9417501-01mL | MyBiosource | 0.1mL | EUR 305 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
|||
| MBS9417501-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) |
|||
| UB-GEN-14030 | UpingBio | 100 ul | EUR 200 |
TNF alpha (TNF) mouse monoclonal antibody, clone 2C8 |
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| 4T10-2C8 | Origene Technologies GmbH | 1 mg | Ask for price |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:1C1] |
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| E45M13855 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 1C1] |
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| E45M13855V-2 | EnoGene | 50 ul | EUR 195 |
P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10) |
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| RA10052-100ul | Reed Biotech | 100 ul | EUR 298 |
P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10) |
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| RA10052-50ul | Reed Biotech | 50 ul | EUR 198 |
CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA802096 | Origene Technologies GmbH | 100 µl | Ask for price |
CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA802096S | Origene Technologies GmbH | 30 µl | Ask for price |
GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA807139 | Origene Technologies GmbH | 100 µl | Ask for price |
GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA807139S | Origene Technologies GmbH | 30 µl | Ask for price |
ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA804173 | Origene Technologies GmbH | 100 µl | Ask for price |
ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA804173S | Origene Technologies GmbH | 30 µl | Ask for price |
PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA803949 | Origene Technologies GmbH | 100 µl | Ask for price |
PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA803949S | Origene Technologies GmbH | 30 µl | Ask for price |
FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA503996 | Origene Technologies GmbH | 100 µl | Ask for price |
FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA503996S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529 |
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| CABT-Z181R | Creative Diagnostics | 100 µg; 500 µg | Ask for price |
|
Description: Mouse |
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Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA500838 | Origene Technologies GmbH | 100 µl | Ask for price |
Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
|||
| TA500838S | Origene Technologies GmbH | 30 µl | Ask for price |
Biotinylated Mouse TNF-α Monoclonal Antibody, Rabbit MAb（DET） |
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| RM98000 | Abclonal | 100μg | EUR 1820.85 |
TNF alpha (TNF) mouse monoclonal antibody, clone 2C8, Aff - Purified |
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| AM26058PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Mouse Anti-Human TNF-α monoclonal antibody, clone C-G8 |
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| CABT-ZB421 | Creative Diagnostics | 200 µg | EUR 810 |
|
Description: Mouse |
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Mouse Anti-Human TNF-α monoclonal antibody, clone C-D8 |
|||
| CABT-ZB423 | Creative Diagnostics | 200 µg | EUR 810 |
|
Description: Mouse |
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TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified |
|||
| AM33351PU-S | Origene Technologies GmbH | 100 µg | Ask for price |
TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified |
|||
| AM33351PU-T | Origene Technologies GmbH | 20 µg | Ask for price |
P63-α Mouse Monoclonal Antibody(4C12) |
|||
| E12-768 | EnoGene | 100μg/100μl | EUR 255 |
|
Description: Available in various conjugation types. |
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P63-α Mouse Monoclonal Antibody（4C12） |
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| RA10254-100ul | Reed Biotech | 100 ul | EUR 298 |
P63-α Mouse Monoclonal Antibody（4C12） |
|||
| RA10254-50ul | Reed Biotech | 50 ul | EUR 198 |
TNF Monoclonal Antibody |
|||
| MBS7135234-005mg | MyBiosource | 0.05mg | EUR 150 |
TNF Monoclonal Antibody |
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| MBS7135234-01mg | MyBiosource | 0.1mg | EUR 190 |
TNF Monoclonal Antibody |
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| MBS7135234-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
TNF Monoclonal Antibody |
|||
| MBS7135235-005mg | MyBiosource | 0.05mg | EUR 150 |
TNF Monoclonal Antibody |
|||
| MBS7135235-01mg | MyBiosource | 0.1mg | EUR 190 |
TNF Monoclonal Antibody |
|||
| MBS7135235-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
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| TA500794 | Origene Technologies GmbH | 100 µl | Ask for price |
Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10) |
|||
| TA500794S | Origene Technologies GmbH | 30 µl | Ask for price |
Recombinant Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529S |
|||
| CABT-Z180R | Creative Diagnostics | 100 µg; 500 µg | Ask for price |
|
Description: Mouse |
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TNF alpha (TNF) (115-130) mouse monoclonal antibody, clone 4C6-H6, Supernatant |
|||
| SM1330 | Origene Technologies GmbH | 2 ml | Ask for price |
Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8 |
|||
| APR10497G | Leading Biology | 0.1mg | EUR 580.8 |
|
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P |
|||
TNF Alpha Monoclonal Antibody |
|||
| ABM40205-003ml | Abbkine | 0.03ml | EUR 189.6 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
|||
| ABM40205-01ml | Abbkine | 0.1ml | EUR 346.8 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
|||
| ABM40205-02ml | Abbkine | 0.2ml | EUR 496.8 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
|||
| ABM40206-003ml | Abbkine | 0.03ml | EUR 189.6 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
|||
TNF Alpha Monoclonal Antibody |
|||
| ABM40206-01ml | Abbkine | 0.1ml | EUR 346.8 |
|
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF Alpha Monoclonal Antibody |
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| ABM40206-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
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TNF alpha Monoclonal Antibody |
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| E-AB-22116-120uL | Elabscience Biotech | 120uL | EUR 240 |
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Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22116-200uL | Elabscience Biotech | 200uL | EUR 399 |
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Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22116-20uL | Elabscience Biotech | 20uL | EUR 73 |
|
Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22116-60uL | Elabscience Biotech | 60uL | EUR 143 |
|
Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22159-120uL | Elabscience Biotech | 120uL | EUR 240 |
|
Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22159-200uL | Elabscience Biotech | 200uL | EUR 399 |
|
Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22159-20uL | Elabscience Biotech | 20uL | EUR 73 |
|
Description: Unconjugated |
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TNF alpha Monoclonal Antibody |
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| E-AB-22159-60uL | Elabscience Biotech | 60uL | EUR 143 |
|
Description: Unconjugated |
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TNF Alpha Monoclonal Antibody |
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| BT-MCA1212-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody |
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| BT-MCA1212-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody |
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| JOT-MCA1212-100ul | Jotbody | 100ul | EUR 220 |
TNF Alpha Monoclonal Antibody |
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| JOT-MCA1212-50ul | Jotbody | 50ul | EUR 144 |
TNF alpha monoclonal antibody |
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| MB65982 | Bioworld Biotech | 50ul | EUR 275 |
|
Description: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
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TNF alpha Monoclonal Antibody |
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| MBS2548893-002mL | MyBiosource | 0.02mL | EUR 135 |
TNF alpha Monoclonal Antibody |
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| MBS2548893-006mL | MyBiosource | 0.06mL | EUR 190 |
TNF alpha Monoclonal Antibody |
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| MBS2548893-012mL | MyBiosource | 0.12mL | EUR 265 |
TNF alpha Monoclonal Antibody |
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| MBS2548893-02mL | MyBiosource | 0.2mL | EUR 415 |
TNF alpha Monoclonal Antibody |
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| MBS2548893-5x02mL | MyBiosource | 5x0.2mL | EUR 1835 |
TNF alpha Monoclonal Antibody |
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| MBS2548932-002mL | MyBiosource | 0.02mL | EUR 135 |
TNF alpha Monoclonal Antibody |
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| MBS2548932-006mL | MyBiosource | 0.06mL | EUR 190 |
TNF alpha Monoclonal Antibody |
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| MBS2548932-012mL | MyBiosource | 0.12mL | EUR 265 |
TNF alpha Monoclonal Antibody |
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| MBS2548932-02mL | MyBiosource | 0.2mL | EUR 415 |
TNF alpha Monoclonal Antibody |
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| MBS2548932-5x02mL | MyBiosource | 5x0.2mL | EUR 1835 |
TNF alpha Monoclonal Antibody |
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| MBS9700322-01mL | MyBiosource | 0.1mL | EUR 215 |
TNF alpha Monoclonal Antibody |
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| MBS9700322-5x01mL | MyBiosource | 5x0.1mL | EUR 925 |
TNF alpha Monoclonal Antibody |
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| MBS8519657-01mg | MyBiosource | 0.1mg | EUR 305 |
TNF alpha Monoclonal Antibody |
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| MBS8519657-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519657-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519657-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519657-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519658-01mg | MyBiosource | 0.1mg | EUR 305 |
TNF alpha Monoclonal Antibody |
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| MBS8519658-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519658-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519658-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| MBS8519658-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
TNF alpha Monoclonal Antibody |
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| RD85537A-120uL | Reddot Biotech | 120μL | EUR 360 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85537A-200uL | Reddot Biotech | 200μL | EUR 630 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85537A-20uL | Reddot Biotech | 20μL | EUR 109.5 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85537A-60uL | Reddot Biotech | 60μL | EUR 214.5 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85588A-120uL | Reddot Biotech | 120μL | EUR 360 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85588A-200uL | Reddot Biotech | 200μL | EUR 630 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85588A-20uL | Reddot Biotech | 20μL | EUR 109.5 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF alpha Monoclonal Antibody |
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| RD85588A-60uL | Reddot Biotech | 60μL | EUR 214.5 |
|
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
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TNF-alpha (human) monoclonal antibody (TNF-D) |
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| MBS566313-01mg | MyBiosource | 0.1mg | EUR 410 |
TNF-alpha (human) monoclonal antibody (TNF-D) |
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| MBS566313-5x01mg | MyBiosource | 5x0.1mg | EUR 1795 |
TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1) |
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| TA506513 | Origene Technologies GmbH | 100 µl | Ask for price |
TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1) |
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| TA506513S | Origene Technologies GmbH | 30 µl | Ask for price |
TNF mouse monoclonal antibody, clone CC327, Purified |
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| SM2216P | Origene Technologies GmbH | 500 µg | Ask for price |
TNF alpha (TNF) mouse monoclonal antibody, clone 1D9 |
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| 4T10-1D9 | Origene Technologies GmbH | 1 mg | Ask for price |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 1D9] |
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| E45M13854V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:1H3] |
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| E45M13856 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 1H3] |
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| E45M13856V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:5H8] |
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| E45M18021 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 5H8] |
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| E45M18021V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:4B9] |
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| E45M18025 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 4B9] |
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| E45M18025V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) mouse monoclonal antibody, clone F6C5 |
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| 4T10-F6C5 | Origene Technologies GmbH | 1 mg | Ask for price |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:5A11] |
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| E45M18014 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 5A11] |
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| E45M18014V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone:3H10] |
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| E45M18184 | EnoGene | 100 ug | EUR 595 |
TNF alpha (TNF) Mouse Monoclonal Antibody [Clone 3H10] |
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| E45M18184V-2 | EnoGene | 50 ul | EUR 195 |
TNF alpha (TNF) mouse monoclonal antibody, Azide Free |
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| PM1012A | Origene Technologies GmbH | 500 µg | Ask for price |
TNF Alpha Monoclonal Antibody(Q34) |
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| BT-MCA1210-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q34) |
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| BT-MCA1210-20ul | Jiaxing Korain Biotech Ltd (BT Labs) | 20ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q34) |
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| BT-MCA1210-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q36) |
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| BT-MCA1211-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q36) |
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| BT-MCA1211-20ul | Jiaxing Korain Biotech Ltd (BT Labs) | 20ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q36) |
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| BT-MCA1211-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
|
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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TNF Alpha Monoclonal Antibody(Q34) |
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| JOT-MCA1210-100ul | Jotbody | 100ul | EUR 220 |
TNF Alpha Monoclonal Antibody(Q34) |
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| JOT-MCA1210-50ul | Jotbody | 50ul | EUR 144 |
TNF Alpha Monoclonal Antibody(Q36) |
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| JOT-MCA1211-100ul | Jotbody | 100ul | EUR 220 |
TNF Alpha Monoclonal Antibody(Q36) |
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| JOT-MCA1211-50ul | Jotbody | 50ul | EUR 144 |
TNF alpha (5F3) monoclonal antibody |
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| MB3040 | Bioworld Biotech | 50ul | EUR 398 |
|
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
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TNF alpha (6H2) monoclonal antibody |
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| MB3243 | Bioworld Biotech | 50ul | EUR 398 |
|
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
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TNF alpha (9D9) monoclonal antibody |
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| MB3324 | Bioworld Biotech | 50ul | EUR 398 |
|
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
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TNF alpha Rat monoclonal antibody |
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| MB65864 | Bioworld Biotech | 50ul | EUR 275 |
|
Description: Rat IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide. |
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TNF alpha Monoclonal Antibody (Q36) |
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| MBS9241671-01mL | MyBiosource | 0.1mL | EUR 425 |
TNF alpha Monoclonal Antibody (Q36) |
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| MBS9241671-5x01mL | MyBiosource | 5x0.1mL | EUR 1887 |
TNF alpha Monoclonal antibody(Q34) |
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| MBS9417474-005mL | MyBiosource | 0.05mL | EUR 245 |
TNF alpha Monoclonal antibody(Q34) |
|||
| MBS9417474-01mL | MyBiosource | 0.1mL | EUR 305 |
TNF alpha Monoclonal antibody(Q34) |
|||
| MBS9417474-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
TNF alpha Monoclonal antibody(Q36) |
|||
| MBS9417475-005mL | MyBiosource | 0.05mL | EUR 245 |
Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion
Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.
Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness
A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
- We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
- Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
- Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
- Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
- Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.