plathlab

Using molecular dynamics simulations to prioritize and understand AI-generated

Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular evaluation of 21 circumstances highlighting a frequent affiliation with DICER1 mutations
Herein we evaluated a sequence of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a uncommon neoplasm, to characterize their morphology, genomics, and habits. Sufferers ranged from 27 to 73 (median 52) years and tumors from Four to 15 (median 9) cm, with extrauterine illness famous in two.
Comply with-up (median 16 months) was accessible for 14/21 sufferers; 9 had been alive and properly, 4 died of illness, and one died from different causes. Most tumors (16/21) confirmed predominantly basic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a free myxoid/edematous stroma.
A cambium layer was famous in all; seven had heterologous components (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining 5 neoplasms confirmed solely a minor part (≤20%) of basic morphology, with anaplasia famous in 4 and tumor cell necrosis in three. Probably the most frequent mutations detected had been in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations had been current in 10/19 tumors.
Total, 8/14 DICER1-associated ucERMS confirmed concurrent lack of operate and hotspot mutations in DICER1, which is a characteristic extra more likely to be seen in tumors related to DICER1 syndrome.
Germline information had been accessible for 2 sufferers, each DICER1 wild sort (one with concurrent lack of operate and hotspot alterations). DICER1-associated ucERMS had been extra more likely to present a basic histological look together with heterologous components than DICER1-independent tumors.
No variations in survival had been famous between the 2 teams, however each sufferers with extrauterine illness at prognosis and two with recurrences died from illness. As no sufferers had a recognized private or household historical past of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.

Utilizing molecular dynamics simulations to prioritize and perceive AI-generated cell penetrating peptides

Cell-penetrating peptides have necessary therapeutic purposes in drug supply, however the number of recognized cell-penetrating peptides continues to be restricted. With a promise to speed up peptide improvement, synthetic intelligence (AI) strategies together with deep generative fashions are at present in highlight.
Scientists, nevertheless, are sometimes overwhelmed by an extreme variety of unannotated sequences generated by AI and discover it troublesome to acquire insights to prioritize them for experimental validation. To keep away from this pitfall, we leverage molecular dynamics (MD) simulations to acquire mechanistic info to prioritize and perceive AI-generated peptides.
A mechanistic rating of permeability is computed from 5 steered MD simulations ranging from totally different preliminary constructions predicted by homology modelling. To compensate for variability of predicted constructions, the rating is computed with pattern variance penalization so {that a} peptide with constant behaviour is extremely evaluated.
Our computational pipeline involving deep studying, homology modelling, MD simulations and synthesizability evaluation generated 24 novel peptide sequences. The highest-scoring peptide confirmed a constant sample of conformational change in all simulations no matter preliminary constructions.
Because of wet-lab-experiments, our peptide confirmed higher permeability and weaker toxicity compared to a clinically used peptide, TAT. Our consequence demonstrates how MD simulations can help de novo peptide design by offering mechanistic info supplementing statistical inference.
plathlab
plathlab

TNF-α Polyclonal Antibody

A71438-100 100 ul
EUR 423.5

Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10

AMM04145G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E

Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10

APR10588G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-100ul 100ul
EUR 302.4

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-50ul 50ul
EUR 224.4

TNF-α Rabbit pAb

A0277-100ul 100 ul
EUR 369.6

TNF-α Rabbit pAb

A0277-200ul 200 ul
EUR 550.8

TNF-α Rabbit pAb

A0277-20ul 20 ul
EUR 219.6

TNF-α Rabbit pAb

A0277-50ul 50 ul
EUR 267.6

TNF-α Rabbit pAb

A11534-100ul 100 ul
EUR 369.6

TNF-α Rabbit pAb

A11534-200ul 200 ul
EUR 550.8

TNF-α Rabbit pAb

A11534-20ul 20 ul
EUR 219.6

TNF-α Rabbit pAb

A11534-50ul 50 ul
EUR 267.6

TNF-α, His, Human

HY-P7416 50ug
EUR 362.4

TNF-α, His, Mouse

HY-P7417 50ug
EUR 583.2

Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative

100-210-TNF 1 kit
EUR 578.4

Marmoset TNF-α ELISPOT antibody pair

CT962-10 10-plate
EUR 633.6

Marmoset TNF-α ELISPOT antibody pair

CT962-20 20-plate
EUR 1107.6

Monkey TNF-α ELISPOT antibody pair

CT617-10 10-plate
EUR 633.6

Monkey TNF-α ELISPOT antibody pair

CT617-20 20-plate
EUR 1107.6

Human TNF-α ELISPOT antibody pair

CT647-10 10-plate
EUR 633.6

Human TNF-α ELISPOT antibody pair

CT647-20 20-plate
EUR 1107.6

Mouse TNF-α ELISPOT antibody pair

CT661-10 10-plate
EUR 633.6

Mouse TNF-α ELISPOT antibody pair

CT661-20 20-plate
EUR 1107.6

Rat TNF-α ELISA antibody pair

CT704-10 10-plate
EUR 656.4

Rat TNF-α ELISA antibody pair

CT704-20 20-plate
EUR 1118.4

Monkey TNF-α ELISA antibody pair

CT717-10 10-plate
EUR 656.4

Monkey TNF-α ELISA antibody pair

CT717-20 20-plate
EUR 1118.4

Human TNF-α ELISA antibody pair

CT747-10 10-plate
EUR 656.4

Human TNF-α ELISA antibody pair

CT747-20 20-plate
EUR 1118.4

Mouse TNF-α ELISA antibody pair

CT761-10 10-plate
EUR 656.4

Mouse TNF-α ELISA antibody pair

CT761-20 20-plate
EUR 1118.4

Marmoset TNF-α ELISA antibody pair

CT772-10 10-plate
EUR 656.4

Marmoset TNF-α ELISA antibody pair

CT772-20 20-plate
EUR 1118.4

TNF ? Monoclonal Antibody

EM1197-100ul 100ul
EUR 334.8
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

TNF ? Monoclonal Antibody

EM1197-50ul 50ul
EUR 248.4
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100-100ul 100ul
EUR 302.4

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-10ug 10ug
EUR 201.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-50ug 50ug
EUR 486
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Swine TNF-α ELISA Kit

DEIA-T6108 96T
EUR 639.6
Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product.

Mouse TNF-α ELISA kit

DEIA7391 96T
EUR 889.2
Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support.

Marmoset TNF-α ELISPOT kit

CT938-PR2 2-plate
EUR 498

Marmoset TNF-α ELISPOT kit

CT938-PR5 5-plate
EUR 667.2

Rat TNF-α ELISA kit

CT075A 5-plate
EUR 554.4

Monkey TNF-α ELISPOT kit

CT133-PB2 2-plate
EUR 498

Monkey TNF-α ELISPOT kit

CT133-PB5 5-plate
EUR 681.6

Monkey TNF-α ELISPOT kit

CT133-PR2 2-plate
EUR 498

Monkey TNF-α ELISPOT kit

CT133-PR5 5-plate
EUR 667.2

Monkey TNF-α ELISPOT kit

CT133-T2 2-plate
EUR 432

Monkey TNF-α ELISPOT kit

CT133-T5 5-plate
EUR 694.8

Monkey TNF-α ELISA kit

CT148A 5-plate
EUR 554.4

Human TNF-α ELISA kit

CT209A 5-plate
EUR 554.4

Human TNF-α ELISPOT kit

CT237-PB2 2-plate
EUR 498

Human TNF-α ELISPOT kit

CT237-PB5 5-plate
EUR 681.6

Human TNF-α ELISPOT kit

CT237-PR2 2-plate
EUR 498

Human TNF-α ELISPOT kit

CT237-PR5 5-plate
EUR 667.2

Human TNF-α ELISPOT kit

CT237-T2 2-plate
EUR 432

Human TNF-α ELISPOT kit

CT237-T5 5-plate
EUR 694.8

Mouse TNF-α ELISA kit

CT303A 5-plate
EUR 554.4

Mouse TNF-α ELISPOT kit

CT322-PB2 2-plate
EUR 498

Mouse TNF-α ELISPOT kit

CT322-PB5 5-plate
EUR 681.6

Mouse TNF-α ELISPOT kit

CT322-PR2 2-plate
EUR 498

Mouse TNF-α ELISPOT kit

CT322-PR5 5-plate
EUR 667.2

Mouse TNF-α ELISPOT kit

CT322-T2 2-plate
EUR 432

Mouse TNF-α ELISPOT kit

CT322-T5 5-plate
EUR 694.8

Marmoset TNF-α ELISA kit

CT342A 5-plate
EUR 554.4

human TNF-α,His tag

E410A13-10 100μg
EUR 832.8

TNF-α (31-45), human

HY-P1860 1mg
EUR 432

Recombinant Mouse TNF α Protein

RP00816 10 μg
EUR 219.6

α-SMA Monoclonal Antibody

40482-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40482-50ul 50ul
EUR 224.4

α-SMA Monoclonal Antibody

40495-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40495-50ul 50ul
EUR 224.4

Anti-TNF-α (Golimumab), Human IgG1 Antibody

A2141-100 100 µg
EUR 612

Anti-TNF-α (Certolizumab Pegol), Humanized Antibody

A2142-100 100 µg
EUR 612

Genorise® Sheep TNF-α polyclonal antibody

GR130002 100 µg
EUR 477.6

Genorise® Mouse TNF-α polyclonal antibody

GR131002 100 µg
EUR 477.6

Genorise® Rat TNF-α polyclonal antibody

GR132002 100 µg
EUR 477.6

Genorise® Rabbit TNF-α Polyclonal antibody

GR180018 100 mg
EUR 477.6

Genorise® Monkey TNF-α Polyclonal antibody

GR184062 100 mg
EUR 477.6

Genorise® Hamster TNF-α polyclonal antibody

GR208002 100 µg
EUR 477.6

Genorise® Feline TNF-α polyclonal antibody

GR195002 100 µg
EUR 477.6

Goat Tumor necrosis factor α,TNF-α ELISA KIT

CN-00367S1 96T
EUR 548.4

Goat Tumor necrosis factor α,TNF-α ELISA KIT

CN-00367S2 48T
EUR 367.2

PoFAine tumor necrosis factor α,TNF-α ELISA Kit

CN-01217P1 96T
EUR 564

PoFAine tumor necrosis factor α,TNF-α ELISA Kit

CN-01217P2 48T
EUR 384

Rat Tumor necrosis factor α,TNF-α ELISA KIT

CN-01587R1 96T
EUR 530.4

Rat Tumor necrosis factor α,TNF-α ELISA KIT

CN-01587R2 48T
EUR 351.6

Human Tumor necrosis factor α,TNF-α ELISA KIT

CN-03277H1 96T
EUR 542.4

Human Tumor necrosis factor α,TNF-α ELISA KIT

CN-03277H2 48T
EUR 362.4

Monkey Tumor necrosis factor α,TNF-α ELISA KIT

CN-02231M1 96T
EUR 592.8

Monkey Tumor necrosis factor α,TNF-α ELISA KIT

CN-02231M2 48T
EUR 412.8

Mouse Tumor necrosis factor α,TNF-α ELISA KIT

CN-02415M1 96T
EUR 548.4

Mouse Tumor necrosis factor α,TNF-α ELISA KIT

CN-02415M2 48T
EUR 367.2

Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit

EHA0004 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 1.875pg/ml

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0772RT-48T 48T
EUR 380.4

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0772RT-96T 96T
EUR 595.2

Bovine tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0017BV-48T 48T
EUR 403.2

Bovine tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0017BV-96T 96T
EUR 640.8

Human Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0122HM-48T 48T
EUR 346.8

Human Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0122HM-96T 96T
EUR 559.2

Mouse Tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0130MS-48T 48T
EUR 403.2

Mouse Tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0130MS-96T 96T
EUR 640.8

Chicken Tumor necrosis factor α,TNF-α ELISA KIT

QY-E80030 96T
EUR 511.2

Human Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E00182 96T
EUR 433.2

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E10880 96T
EUR 433.2

Goat Tumor necrosis factor α,TNF-α ELISA KIT

QY-E140007 96T
EUR 495.6

Sheep Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E140060 96T
EUR 495.6

Mouse Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E21543 96T
EUR 433.2

Porcine tumor necrosis factor α,TNF-α ELISA Kit

QY-E40006 96T
EUR 472.8

Bovine Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E60007 96T
EUR 511.2

Canine Tumor necrosis factor α,TNF-α ELISA Kit

QY-E70025 96T
EUR 511.2

anti-STAT6 (6C10)

LF-MA10315 50 ug
EUR 435.6
Description: Mouse monoclonal to STAT6

Anti-STAT6 (6C10)

YF-MA15643 200 ul
EUR 435.6
Description: Mouse monoclonal to STAT6

Anti-BRD3 (6C10)

YF-MA16265 50 ug
EUR 435.6
Description: Mouse monoclonal to BRD3

Anti-BRD3 (6C10)

YF-MA16266 200 ul
EUR 435.6
Description: Mouse monoclonal to BRD3

pAb rabbit anti-rat TNF-α

CT062 0.5 mg
EUR 220.8

mAb mouse anti-human TNF-α

CT258 0.5 mg
EUR 312

mAb mouse anti-human TNF-α

CT260 0.5 mg
EUR 312

mAb mouse anti-human TNF-α

CT271 0.5 mg
EUR 312

Recombinant mouse TNF-α (E.coli-derived)

CT304 10 µg
EUR 291.6

Recombinant mouse TNF-α (E.coli-derived)

CT305 100 µg
EUR 717.6

pAb rabbit anti-mouse TNF-α

CT315 0.5 mg
EUR 220.8

TNF-α (31-45), human (TFA)

HY-P1860A 5mg
EUR 1176

TNF Alpha Monoclonal Antibody

ABM40205-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit

CN-00228G1 96T
EUR 564

Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit

CN-00228G2 48T
EUR 384

Guinea pig Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E90069 96T
EUR 573.6

Genorise® Guinea Pig TNF-α polyclonal antibody

GR174002 100 µg
EUR 477.6

Genorise® Biotinylated Hamster TNF-α polyclonal antibody

GR209002 100 µg
EUR 477.6

Genorise® Biotinylated Rabbit TNF-α Polyclonal antibody

GR191018 50 mg
EUR 477.6

Genorise® Biotinylated Feline TNF-α polyclonal antibody

GR196002 100 µg
EUR 477.6

Genorise® Biotinylated Monkey TNF-α Polyclonal antibody

GR197014 100 mg
EUR 477.6

HSP90 α Monoclonal antibody(1F6)

44076-100ul 100ul
EUR 302.4

HSP90 α Monoclonal antibody(7D6)

44078-100ul 100ul
EUR 302.4

α-tubulin Mouse Monoclonal Antibody

37981-100ul 100ul
EUR 302.4

α-tubulin Mouse Monoclonal Antibody

37981-50ul 50ul
EUR 224.4

Anti-Thioredoxin / TRX (6C10)

YF-MA15994 100 ug
EUR 435.6
Description: Mouse monoclonal to Thioredoxin / TRX

Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant

C036-10ug 10ug
EUR 181.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant

C036-1mg 1mg
EUR 2154
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant

C036-500ug 500ug
EUR 1527.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant

C036-50ug 50ug
EUR 412.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Human IFN-γ / TNF-α FluoroSpot kit

CT851-F2 2-plate
EUR 694.8

Monkey IFN-γ / TNF-α FluoroSpot kit

CT901-F2 2-plate
EUR 694.8

Genorise® Recombinant Rat TNF-α protein

GR125003 5 µg
EUR 342

Genorise® Chicken TNF-α Expression Plasmid

GR148005 10 µg
EUR 262.8

Nori® duck TNF-α ELISA Kit

GR149025 96-well
EUR 553.2

Nori® Hamster TNF-α ELISA Kit

GR172146 96-well
EUR 553.2

Genorise® Recombinant turkey TNF-α protein

GR185003 5 mg
EUR 342

Nori® Turkey TNF-α ELISA Kit

GR187025 96-well
EUR 553.2

Nori® Feline TNF-α ELISA Kit

GR188146 96-well
EUR 553.2

Nori® Ferret TNF-α ELISA Kit

GR201055 96-well
EUR 553.2

Nori® Salmon TNF-α ELISA Kit

GR202055 96-well
EUR 553.2

Nori® Zebrafish TNF-α ELISA Kit

GR206055 96-well
EUR 553.2

Nori® Ovine TNF-α DyLight 488 Polyclonal Antibody

GR203001 50 µg
EUR 477.6

17-α-hydoxy progesterone monoclonal antibody

10R-11483 1 mg
EUR 891.6
Description: Mouse anti-17-α-hydoxy progesterone monoclonal antibody

Human TNF α converting enzyme,TACE ELISA Kit

CN-03416H1 96T
EUR 555.6

Human TNF α converting enzyme,TACE ELISA Kit

CN-03416H2 48T
EUR 374.4

pAb rabbit anti-rat TNF-α Biotin-labeled

CT064 0.5 mg
EUR 416.4

pAb rabbit anti-mouse TNF-α Biotin labeled

CT332 0.5 mg
EUR 416.4

Human TNF α converting enzyme(TACE)ELISA Kit

GA-E0865HM-48T 48T
EUR 346.8

Human TNF α converting enzyme(TACE)ELISA Kit

GA-E0865HM-96T 96T
EUR 559.2

Human TNF α converting enzyme(TACE)ELISA Kit

QY-E00180 96T
EUR 433.2

TNF Receptor II recombinant monoclonal antibody

A5046 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA

Monoclonal TNF-alpha Antibody, Clone: 2A9B9

APR13767G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E

Monoclonal TNF alpha Antibody, Clone: EP1085Y

APR10496G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB

Mouse anti Canine TNF monoclonal antibody

CABT-L129 500ug
EUR 982.8

Mouse anti Rat TNF monoclonal antibody

CABT-L378 100ug
EUR 858

Mouse anti Porcine TNF monoclonal antibody

CABT-L382 500ug
EUR 1008

Mouse anti Porcine TNF monoclonal antibody

CABT-L383 250 ug
EUR 1070.4

α tubulin Mouse Monoclonal Antibody(Zebrafish Specific)

38059-100ul 100ul
EUR 302.4

α tubulin Mouse Monoclonal Antibody(Zebrafish Specific)

38059-50ul 50ul
EUR 224.4

α-tubulin (Acetyl Lys40) Monoclonal Antibody(5H5)

HW204-100ul 100ul
EUR 302.4

Recombinant Human Tumor Necrosis Factor-alpha (rHu TNF-α)

AK9887-0025 25µg
EUR 840

Recombinant Human Tumor Necrosis Factor-alpha (rHu TNF-α)

AK9887-0050 50µg
EUR 1320

Rat TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit

ER1393 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rabbit TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit

ERB0126 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml

Porcine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit

EP0159 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 18.75pg/ml

Canine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit

ECA0020 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 9.375pg/ml

Bovine TNF-α(Tumor necrosis factor alpha) ELISA Kit

EB0008 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 0.094 ng/ml

Sheep TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit

ESH0025 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 9.375pg/ml

Nori® Equine TNF-β/Lymphotoxin-α ELISA Kit

GR106637 96-well
EUR 553.2

Nori® Bovine TNF-β/Lymphotoxin-α ELISA Kit

GR112086 96-well
EUR 553.2

Nori® Porcine TNF-β/Lymphotoxin-α ELISA Kit

GR113238 96-well
EUR 553.2

Nori® Canine TNF-β/Lymphotoxin-α ELISA Kit

GR115137 96-well
EUR 553.2

Nori® Ovine TNF-β/Lymphotoxin-α ELISA Kit

GR116039 96-well
EUR 553.2

Camel Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit

QY-E120067 96T
EUR 573.6

Mouse anti Guinea Pig TNF monoclonal antibody

CABT-L155 500ug
EUR 982.8

Intercourse-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion

Goal: We beforehand demonstrated that intercourse influences response tovimmune-checkpoint inhibitors. Right here we examine sex-based variations within the molecular mechanisms of anticancer immune-response and immune evasion in sufferers with NSCLC.
Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 totally different datasets; b) 327 tumor-samples extensively characterised on the molecular stage from the TRACERx lung examine; c) two impartial cohorts of respectively 329 and 391 sufferers with superior NSCLC handled with anti-PD1/anti-PDL1 medication.
Outcomes: As in contrast with males, the tumor microenvironment (TME) of ladies was considerably enriched for a lot of innate and adaptive immune cell-types, together with particular T-cell subpopulations. NSCLCs of women and men exploited totally different mechanisms of immune evasion.
The TME of females was characterised by considerably larger T-cell dysfunction standing, greater expression of inhibitory immune-checkpoint molecules and better abundance of immune-suppressive cells, together with Most cancers Related Fibroblasts, MDSCs and Regulatory T-cells. In contrast, the TME of males was considerably enriched for a T-cells excluded phenotype.
We reported information supporting impaired neoantigens presentation to immune system in tumors of males, as molecular mechanism explaining the findings noticed. Lastly, in step with our outcomes, we confirmed vital sex-based variations within the affiliation between TMB and end result of sufferers with superior NSCLC handled with anti-PD1/PDL1 medication.
Conclusions: We demonstrated significant sex-based variations of anticancer immune response and immune evasion mechanisms, which may be exploited to enhance immunotherapy efficacy for each ladies and men.

Serum high-molecular-weight adiponectin and response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness

A greater baseline renal operate is related to a greater response to sodium-glucose co-transporter-2 inhibitors in sufferers with sort 2 diabetes. Low serum adiponectin is related to visceral fats accumulation and hepatic steatosis.
  • We investigated the connection between baseline serum adiponectin and glycemic response to dapagliflozin in sufferers with sort 2 diabetes and non-alcoholic fatty liver illness (NAFLD). In a randomized, active-controlled, open-label trial, 57 sufferers with sort 2 diabetes and NAFLD had been randomized to both the dapagliflozin (5 mg/d) group or the management group.
  • Each teams had been handled for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA equipment. Visceral fats space (VFA) was measured by twin bioelectrical impedance evaluation.
  • Hepatic steatosis was assessed by the managed attenuation parameter (CAP) measured by a transient elastography (FibroScan). Remedy with dapagliflozin considerably decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Each VFA and CAP decreased within the dapagliflozin group.
  • Baseline serum HMW adiponectin was negatively correlated with modifications in HbA1c from baseline to 24 weeks with dapagliflozin remedy. Within the multivariate evaluation, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) had been impartial determinants for the change (discount) in HbA1c.
  • Within the dapagliflozin group, the change in HbA1c was positively correlated with the modifications of CAP, however negatively correlated with the change in serum HMW adiponectin. In conclusion, a decrease serum stage of HMW adiponectin was related to a greater response to dapagliflozin in sufferers with sort 2 diabetes and NAFLD.Trial registration numberUMIN000022155.

 

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